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Tbio
PHF12
PHD finger protein 12

Protein Summary
Description
Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional AES complexes to DNA.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268756
  • ENSP00000268756
  • ENSG00000109118
  • ENST00000332830
  • ENSP00000329933
  • ENST00000577226
  • ENSP00000465161

Symbol
  • KIAA1523
  • PF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.93
protein domain
0.92
transcription factor
0.81
cellular component
0.79
molecular function
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 426.01   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 426.01   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (114)
1 – 10 of 114
MORF4L1
Tbio
Family: Epigenetic
Novelty: 0.01696001
p_int: 0.999999989
p_ni: 9e-9
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
RBBP7
Tbio
Novelty: 0.01795364
p_int: 0.999999974
p_ni: 2.5e-8
p_wrong: 1e-9
Score: 0.976
Data Source: BioPlex,STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
p_int: 0.9999999
p_ni: 9.9e-8
Score: 0.987
Data Source: BioPlex,STRINGDB
MORF4L2
Tbio
Novelty: 0.09897629
p_int: 0.999988131
p_ni: 0.000011868
Score: 0.974
Data Source: BioPlex,STRINGDB
SIN3A
Tbio
Novelty: 0.00747207
Score: 0.998
Data Source: STRINGDB
HDAC2
Tclin
Family: Epigenetic
Novelty: 0.0011024
Score: 0.986
Data Source: STRINGDB
SIN3B
Tbio
Novelty: 0.04097105
Score: 0.985
Data Source: STRINGDB
HDAC3
Tclin
Family: Epigenetic
Novelty: 0.00393172
Score: 0.972
Data Source: STRINGDB
HDAC8
Tclin
Family: Epigenetic
Novelty: 0.0023827
Score: 0.958
Data Source: STRINGDB
ING2
Tbio
Family: Epigenetic
Novelty: 0.02424031
Score: 0.952
Data Source: STRINGDB
Publication Statistics
PubMed Score  426.01

PubMed score by year
PubTator Score  167.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer