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Tbio
SLC25A21
Mitochondrial 2-oxodicarboxylate carrier

Protein Summary
Description
Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate. SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[supplied by OMIM, Apr 2004]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331299
  • ENSP00000329452
  • ENSG00000183032
  • ENST00000555449
  • ENSP00000451873

Symbol
  • ODC
  • ODC
  • ODC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.82
transcription factor
0.75
cell type or tissue
0.74
transcription factor binding site profile
0.7
phenotype
0.67


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.5   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.5   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Cleft palate
1
1
0
1.4
71.6
mean corpuscular volume
1
1
1
50.5
body height
1
1
1
41.8
reticulocyte count
1
1
1
32.2
airway imaging measurement
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Cleft palate
0
1.4
71.6
mean corpuscular volume
1
50.5
body height
1
41.8
reticulocyte count
1
32.2
airway imaging measurement
1
29
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 21
VGNC:12533
467433
Macaque
solute carrier family 25 member 21
697370
Mouse
MGI:2445059
217593
Rat
RGD:621444
171151
Dog
solute carrier family 25 member 21
VGNC:46300
490655
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 21
Macaque
solute carrier family 25 member 21
Mouse
Rat
Dog
solute carrier family 25 member 21
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BQT8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Lysine catabolism (R-HSA-71064)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Lysine catabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Lysine catabolism
Metabolism
Metabolism of amino acids and derivatives
Protein-Protein Interactions (57)
1 – 10 of 57
TBX20
Tbio
Family: TF
Novelty: 0.01290983
p_int: 0.999989585
p_ni: 0.000010384
p_wrong: 3.1e-8
Score: 0.859
Data Source: BioPlex,STRINGDB
DNASE1L2
Tbio
Family: Enzyme
Novelty: 0.0152658
p_int: 0.978605273
p_ni: 0.021393925
p_wrong: 8.02e-7
Score: 0.822
Data Source: BioPlex,STRINGDB
PPIE
Tbio
Family: Enzyme
Novelty: 0.01586411
p_int: 0.964032939
p_ni: 0.035967061
Score: 0.161
Data Source: BioPlex,STRINGDB
OGDH
Tbio
Family: Enzyme
Novelty: 0.00674601
Score: 0.756
Data Source: STRINGDB
MIPOL1
Tbio
Novelty: 0.2456
Score: 0.749
Data Source: STRINGDB
SLC39A11
Tbio
Family: Transporter
Novelty: 0.09770302
Score: 0.702
Data Source: STRINGDB
PAX9
Tbio
Family: TF
Novelty: 0.00581813
Score: 0.684
Data Source: STRINGDB
CERS6
Tbio
Family: TF
Novelty: 0.01956925
Score: 0.673
Data Source: STRINGDB
ARHGAP1
Tbio
Family: Enzyme
Novelty: 0.00668626
Score: 0.643
Data Source: STRINGDB
CFAP57
Tdark
Novelty: 0.33594432
Score: 0.591
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.50

PubMed score by year
PubTator Score  5.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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