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Tbio
SERPINA7
Thyroxine-binding globulin

Protein Summary
Description
Major thyroid hormone transport protein in serum. There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327674
  • ENSP00000329374
  • ENSG00000123561
  • ENST00000372563
  • ENSP00000361644

Symbol
  • TBG
  • TBG
  • TBGQTL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.68
biological process
0.6
chemical
0.57
disease
0.57
metabolite
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1193.43   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 406   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1193.43   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 406   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (85)
1 – 10 of 85
DHFR2
Tbio
Family: Enzyme
Novelty: 0.02374466
p_int: 0.994360006
p_ni: 0.00563394
p_wrong: 0.000006053
Score: 0.2
Data Source: BioPlex,STRINGDB
RTL8C
Tbio
Novelty: 0.20316911
p_int: 0.952014002
p_ni: 0.046652432
p_wrong: 0.001333566
Score: 0.261
Data Source: BioPlex,STRINGDB
MIA3
Tbio
Novelty: 0.02784348
p_int: 0.91203932
p_ni: 0.08796068
Score: 0.239
Data Source: BioPlex,STRINGDB
ALB
Tchem
Novelty: 0.00000616
Score: 0.878
Data Source: STRINGDB
TTR
Tclin
Novelty: 0.0001199
Score: 0.874
Data Source: STRINGDB
AHSG
Tbio
Novelty: 0.00112502
Score: 0.841
Data Source: STRINGDB
UGT2B10
Tbio
Family: Enzyme
Novelty: 0.03135595
Score: 0.778
Data Source: STRINGDB
F2
Tclin
Family: Enzyme
Novelty: 0.00004833
Score: 0.772
Data Source: STRINGDB
SERPINA11
Tdark
Novelty: 0.80916776
Score: 0.766
Data Source: STRINGDB
FGA
Tbio
Novelty: 0.00107227
Score: 0.762
Data Source: STRINGDB
Publication Statistics
PubMed Score  1193.43

PubMed score by year
PubTator Score  1125.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer