You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
IGLL1
Immunoglobulin lambda-like polypeptide 1

Protein Summary
Description
Critical for B-cell development. The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249053
  • ENSP00000249053
  • ENSG00000128322
  • ENST00000330377
  • ENSP00000329312

Symbol
  • IGL1
  • IGO
  • 14.1
  • AGM2
  • IGL1
  • IGL5
  • IGLL
  • IGVPB
  • CD179b
  • VPREB2
  • IGLJ14.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.64
virus perturbation
0.59
protein domain
0.58
cell line
0.53
cell type or tissue
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 317.47   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 266   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 317.47   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Hemostasis
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (48)
1 – 10 of 48
IGLL5
Tbio
Novelty: 0.00459259
p_int: 0.999969936
p_ni: 1.7e-8
p_wrong: 0.000030047
Score: 0.932
Data Source: BioPlex,STRINGDB
VPREB1
Tbio
Novelty: 0.00742085
Score: 0.998
Data Source: Reactome,STRINGDB
VPREB3
Tbio
Novelty: 0.13999956
Score: 0.973
Data Source: Reactome,STRINGDB
IGLC1
Tdark
Novelty: 0.00459259
Score: 0.932
Data Source: STRINGDB
IGHV3-11
Tdark
Novelty: 0.09180836
Score: 0.903
Data Source: STRINGDB
JCHAIN
Tbio
Novelty: 0.00172454
Score: 0.878
Data Source: STRINGDB
CD79B
Tclin
Novelty: 0.00227414
Score: 0.836
Data Source: STRINGDB
CD79A
Tbio
Novelty: 0.00118942
Score: 0.828
Data Source: STRINGDB
IKZF1
Tbio
Family: TF
Novelty: 0.0016117
Score: 0.698
Data Source: STRINGDB
MZB1
Tbio
Novelty: 0.04147497
Score: 0.671
Data Source: STRINGDB
Publication Statistics
PubMed Score  317.47

PubMed score by year
PubTator Score  79.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer