You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
STAC3
SH3 and cysteine-rich domain-containing protein 3

Protein Summary
Description
Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels (PubMed:23736855, PubMed:29078335). Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane. Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane (By similarity). Slows down the inactivation rate of the calcium channel CACNA1C (PubMed:29078335). The protein encoded by this gene is a component of the excitation-contraction coupling machinery of muscles. This protein is a member of the Stac gene family and contains an N-terminal cysteine-rich domain and two SH3 domains. Mutations in this gene are a cause of Native American myopathy. [provided by RefSeq, Nov 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332782
  • ENSP00000329200
  • ENSG00000185482
  • ENST00000546246
  • ENSP00000441515
  • ENST00000554578
  • ENSP00000452068

Symbol
  • NAM
  • MYPBB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.82
virus perturbation
0.64
tissue sample
0.59
cell type or tissue
0.56
cell line
0.55


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.98   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.98   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SH3 and cysteine rich domain 3
VGNC:5603
452009
Macaque
SH3 and cysteine rich domain 3
714531
Mouse
MGI:3606571
237611
Rat
RGD:1308964
362895
Dog
SH3 and cysteine rich domain 3
VGNC:46872
481125
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SH3 and cysteine rich domain 3
Macaque
SH3 and cysteine rich domain 3
Mouse
Rat
Dog
SH3 and cysteine rich domain 3
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96MF2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (77)
1 – 10 of 77
ANKLE2
Tbio
Novelty: 0.0995907
p_int: 0.999909167
p_ni: 0.000090827
p_wrong: 6e-9
Score: 0.252
Data Source: BioPlex,STRINGDB
WDR54
Tdark
Novelty: 1.19807122
p_int: 0.972943036
p_ni: 0.027056964
Score: 0.252
Data Source: BioPlex,STRINGDB
GTF2F1
Tbio
Novelty: 0.02118098
p_int: 0.75852165
p_ni: 0.241460411
p_wrong: 0.000017939
Score: 0.239
Data Source: BioPlex,STRINGDB
CACNA1S
Tclin
Family: IC
Novelty: 0.00434282
Score: 0.917
Data Source: STRINGDB
RYR1
Tclin
Family: IC
Novelty: 0.00077827
Score: 0.903
Data Source: STRINGDB
SIRT1
Tchem
Family: Epigenetic
Novelty: 0.00022265
Score: 0.877
Data Source: STRINGDB
CACNA1C
Tclin
Family: IC
Novelty: 0.00099998
Score: 0.786
Data Source: STRINGDB
CACNA2D4
Tbio
Family: IC
Novelty: 0.02238343
Score: 0.751
Data Source: STRINGDB
CACNA1B
Tclin
Family: IC
Novelty: 0.00319692
Score: 0.741
Data Source: STRINGDB
CACNA1D
Tclin
Family: IC
Novelty: 0.00314752
Score: 0.736
Data Source: STRINGDB
Publication Statistics
PubMed Score  31.98

PubMed score by year
PubTator Score  801.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: