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Tbio
CREB3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

Protein Summary
Description
Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827). This gene encodes a member of the oasis bZIP tran ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330387
  • ENSP00000329140
  • ENSG00000182158
  • ENST00000452463
  • ENSP00000410314
  • ENST00000456390
  • ENSP00000403550

Symbol
  • BBF2H7
  • BBF2H7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
kinase perturbation
0.99
transcription factor binding site profile
0.91
virus perturbation
0.88
disease perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.8   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 231   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.8   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 231   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
28.1
total cholesterol measurement
1
1
0
4.7
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
28.1
total cholesterol measurement
0
4.7
28.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cAMP responsive element binding protein 3 like 2
VGNC:13641
738928
Macaque
cAMP responsive element binding protein 3 like 2
714981
Mouse
MGI:2442695
208647
Rat
RGD:1306040
362339
Dog
cAMP responsive element binding protein 3 like 2
VGNC:39598
491369
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cAMP responsive element binding protein 3 like 2
Macaque
cAMP responsive element binding protein 3 like 2
Mouse
Rat
Dog
cAMP responsive element binding protein 3 like 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q70SY1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (42)
CREB3 factors activate genes (R-HSA-8874211)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
CREB3 factors activate genes
Reactome
Metabolism of proteins
Reactome
Unfolded Protein Response (UPR)
Name
Explore in Pharos
Explore in Source
CREB3 factors activate genes
Metabolism of proteins
Unfolded Protein Response (UPR)
Gene Ontology Terms (19)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (89)
1 – 10 of 89
CREB3
Tbio
Family: TF
Novelty: 0.00424318
p_int: 0.999999525
p_ni: 3.56e-7
p_wrong: 1.19e-7
Score: 0.895
Data Source: BioPlex,STRINGDB
CREB3L1
Tbio
Family: TF
Novelty: 0.02295608
p_int: 0.999962414
p_ni: 5.6e-8
p_wrong: 0.000037529
Score: 0.885
Data Source: BioPlex,STRINGDB
MBTPS1
Tchem
Family: Enzyme
Novelty: 0.00845881
Score: 0.956
Data Source: Reactome,STRINGDB
MBTPS2
Tbio
Family: Enzyme
Novelty: 0.00625665
Score: 0.954
Data Source: Reactome,STRINGDB
ATF1
Tchem
Family: TF
Novelty: 0.01450941
Score: 0.905
Data Source: STRINGDB
ATF4
Tbio
Family: TF
Novelty: 0.00253408
Score: 0.872
Data Source: STRINGDB
CREB3L3
Tbio
Family: TF
Novelty: 0.02519904
Score: 0.854
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.849
Data Source: STRINGDB
CREBBP
Tchem
Family: Epigenetic
Novelty: 0.00111166
Score: 0.849
Data Source: STRINGDB
CREB3L4
Tbio
Family: TF
Novelty: 0.02532901
Score: 0.847
Data Source: STRINGDB
Publication Statistics
PubMed Score  35.80

PubMed score by year
PubTator Score  32.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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