You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SIX6
Homeobox protein SIX6

Protein Summary
Description
May be involved in eye development. The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327720
  • ENSP00000328596
  • ENSG00000184302

Symbol
  • OPTX2
  • SIX9
  • Six9
  • ODRMD
  • OPTX2
  • MCOPCT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
co-expressed gene
0.97
PubMedID
0.6
cell type or tissue
0.54
transcription factor binding site profile
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.5   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.5   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
1
1
53.8
Antiglaucoma preparations and miotics use measurement
1
1
1
42.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
53.8
Antiglaucoma preparations and miotics use measurement
1
42.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1341840
20476
Rat
RGD:1310497
314221
Dog
SIX homeobox 6
VGNC:51685
490718
Horse
SIX homeobox 6 [Source:HGNC Symbol;Acc:HGNC:10892]
Pig
SIX homeobox 6
100519236
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
SIX homeobox 6
Horse
SIX homeobox 6 [Source:HGNC Symbol;Acc:HGNC:10892]
Pig
SIX homeobox 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95475-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (81)
1 – 10 of 81
DACH1
Tbio
Novelty: 0.00986576
Score: 0.934
Data Source: STRINGDB
PAX6
Tbio
Family: TF
Novelty: 0.00064695
Score: 0.871
Data Source: STRINGDB
OTX2
Tbio
Family: TF
Novelty: 0.0024536
Score: 0.834
Data Source: STRINGDB
VSX2
Tbio
Family: TF
Novelty: 0.0046733
Score: 0.799
Data Source: STRINGDB
LHX2
Tbio
Family: TF
Novelty: 0.00915095
Score: 0.762
Data Source: STRINGDB
FZD5
Tbio
Family: GPCR
Novelty: 0.01673829
Score: 0.713
Data Source: STRINGDB
TMCO1
Tbio
Novelty: 0.04473381
Score: 0.704
Data Source: STRINGDB
SOX2
Tbio
Family: TF
Novelty: 0.00037089
Score: 0.686
Data Source: STRINGDB
DLX1
Tbio
Family: TF
Novelty: 0.01359424
Score: 0.681
Data Source: STRINGDB
EYA1
Tbio
Novelty: 0.00585286
Score: 0.68
Data Source: STRINGDB
Publication Statistics
PubMed Score  83.50

PubMed score by year
PubTator Score  88.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: