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Tclin
PDE6G
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Protein Classes
Protein Summary
Description
Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331056
  • ENSP00000328412
  • ENSG00000185527
  • ENST00000571004
  • ENSP00000461464
  • ENST00000571224
  • ENSP00000458167

Symbol
  • PDEG
  • PDEG
  • RP57
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
biological process
0.71
cell line
0.61
tissue sample
0.61
cellular component
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.85   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.85   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
dipyridamole
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
1
1
0
1.1
53.9
cognitive function measurement
1
1
1
52
Myopia
1
1
0
1.2
51.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
53.9
cognitive function measurement
1
52
Myopia
0
1.2
51.2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (19)
Activation of the phototransduction cascade (R-HSA-2485179)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the phototransduction cascade
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca2+ pathway
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Activation of the phototransduction cascade
Beta-catenin independent WNT signaling
Ca2+ pathway
G alpha (i) signalling events
GPCR downstream signalling
Protein-Protein Interactions (160)
1 – 10 of 160
PDE6A
Tclin
Family: Enzyme
Novelty: 0.02680494
Score: 0.996
Data Source: Reactome,STRINGDB
PDE6B
Tclin
Family: Enzyme
Novelty: 0.001105
Score: 0.995
Data Source: Reactome,STRINGDB
GNGT1
Tbio
Novelty: 0.05291961
Score: 0.993
Data Source: STRINGDB
GNAT1
Tbio
Novelty: 0.03042002
Score: 0.988
Data Source: Reactome,STRINGDB
GNG11
Tbio
Novelty: 0.10721743
Score: 0.985
Data Source: STRINGDB
GNAT2
Tbio
Novelty: 0.01683655
Score: 0.982
Data Source: Reactome,STRINGDB
RGS9
Tbio
Novelty: 0.06662559
Score: 0.974
Data Source: STRINGDB
PDE2A
Tclin
Family: Enzyme
Novelty: 0.00862513
Score: 0.973
Data Source: STRINGDB
CNGA1
Tchem
Family: IC
Novelty: 0.00848214
Score: 0.969
Data Source: STRINGDB
CNGB1
Tbio
Family: IC
Novelty: 0.01034916
Score: 0.963
Data Source: STRINGDB
Publication Statistics
PubMed Score  31.85

PubMed score by year
PubTator Score  6.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer