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Tbio
SNAI3
Zinc finger protein SNAI3

Protein Summary
Description
Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5'-CAGGTG-3' and 5'-CACCTG-3' (By similarity). SNAI3 is a member of the SNAIL gene family, named for the Drosophila snail gene, which plays roles in mesodermal formation during embryogenesis (Katoh and Katoh, 2003 [PubMed 12579345]).[supplied by OMIM, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332281
  • ENSP00000327968
  • ENSG00000185669

Symbol
  • ZNF293
  • SMUC
  • SNAIL3
  • ZNF293
  • Zfp293
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.74
protein domain
0.73
histone modification site profile
0.7
transcription factor
0.59
cell type or tissue
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.57   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.57   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (10)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (15)
1 – 10 of 15
TJP2
Tbio
Novelty: 0.00446681
p_int: 0.999958846
p_ni: 0.000041154
Score: 0.275
Data Source: BioPlex,STRINGDB
STRN3
Tbio
Novelty: 0.10331283
p_int: 0.84348201
p_ni: 0.15651799
Score: 0.226
Data Source: BioPlex,STRINGDB
CDH1
Tbio
Novelty: 0.00010629
Score: 0.953
Data Source: STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
Score: 0.938
Data Source: STRINGDB
MTA3
Tbio
Family: TF
Novelty: 0.02667635
Score: 0.905
Data Source: STRINGDB
MBD3
Tbio
Family: TF
Novelty: 0.04513502
Score: 0.9
Data Source: STRINGDB
TWIST1
Tbio
Family: TF
Novelty: 0.0013639
Score: 0.541
Data Source: STRINGDB
STRIP1
Tbio
Novelty: 0.13320106
Score: 0.516
Data Source: STRINGDB
TWIST2
Tbio
Family: TF
Novelty: 0.00748285
Score: 0.493
Data Source: STRINGDB
CDH2
Tbio
Novelty: 0.00040112
Score: 0.474
Data Source: STRINGDB
Publication Statistics
PubMed Score  28.57

PubMed score by year
PubTator Score  9.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer