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Tbio
TGIF1
Homeobox protein TGIF1

Protein Summary
Description
Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities. The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330513
  • ENSP00000327959
  • ENSG00000177426
  • ENST00000343820
  • ENSP00000339631
  • ENST00000345133
  • ENSP00000343969
  • ENST00000400167
  • ENSP00000383031
  • ENST00000401449
  • ENSP00000385206
  • ENST00000405385
  • ENSP00000384970
  • ENST00000407501
  • ENSP00000384133
  • ENST00000472042
  • ENSP00000449501
  • ENST00000548489
  • ENSP00000447747
  • ENST00000551541
  • ENSP00000450025
  • ENST00000618001
  • ENSP00000483499

Symbol
  • TGIF
  • HPE4
  • TGIF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
kinase perturbation
0.93
PubMedID
0.93
virus perturbation
0.92
transcription factor
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.59   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 341   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.59   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 341   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
54.1
neutrophil count
2
1
2
54.1
monocyte count
1
1
1
50.8
monocyte percentage of leukocytes
1
1
1
34.5
mean reticulocyte volume
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
54.1
neutrophil count
2
54.1
monocyte count
1
50.8
monocyte percentage of leukocytes
1
34.5
mean reticulocyte volume
1
30.2
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (22)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (R-HSA-2173795)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Name
Explore in Pharos
Explore in Source
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Gene Ontology Terms (11)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (47)
1 – 10 of 47
SMAD2
Tbio
Family: TF
Novelty: 0.00040166
Score: 0.977
Data Source: Reactome,STRINGDB
SMAD3
Tbio
Family: TF
Novelty: 0.00048058
Score: 0.952
Data Source: Reactome,STRINGDB
CTBP1
Tbio
Novelty: 0.00243818
Score: 0.95
Data Source: STRINGDB
SIN3A
Tbio
Novelty: 0.00747207
Score: 0.94
Data Source: STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
Score: 0.94
Data Source: Reactome,STRINGDB
SMAD4
Tbio
Family: TF
Novelty: 0.00047069
Score: 0.93
Data Source: Reactome,STRINGDB
SAP30
Tbio
Family: Enzyme
Novelty: 0.03474176
Score: 0.918
Data Source: STRINGDB
SERPINE1
Tchem
Novelty: 0.00017629
Score: 0.911
Data Source: STRINGDB
HDAC2
Tclin
Family: Epigenetic
Novelty: 0.0011024
Score: 0.903
Data Source: STRINGDB
RBBP4
Tbio
Novelty: 0.01062843
Score: 0.903
Data Source: STRINGDB
Publication Statistics
PubMed Score  56.59

PubMed score by year
PubTator Score  104

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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