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Tbio
SMDT1
Essential MCU regulator, mitochondrial

Protein Summary
Description
Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria (PubMed:24231807, PubMed:26774479, PubMed:27099988). Required to bridge the calcium-sensing proteins MICU1 and MICU2 with the calcium-conducting subunit MCU (PubMed:24231807). Plays a central role in regulating the uniplex complex response to intracellular calcium signaling (PubMed:27099988). Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling (PubMed:27099988). This gene encodes a core regulatory component of a calcium channel in the mitochondrial inner membrane. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331479
  • ENSP00000327467
  • ENSG00000183172
  • ENST00000571525
  • ENSP00000459368
  • ENSG00000272901
  • ENST00000607293
  • ENSP00000475471
  • ENSG00000272835
  • ENST00000615504
  • ENSP00000485029
  • ENSG00000274112

Symbol
  • C22orf32
  • EMRE
  • DDDD
  • EMRE
  • C22orf32
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.79
small molecule perturbation
0.77
kinase perturbation
0.66
transcription factor binding site profile
0.64
tissue sample
0.61


Related Tools
GENEVA
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.47   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 19   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.47   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 19   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H4I9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Mitochondrial calcium ion transport (R-HSA-8949215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial calcium ion transport
Reactome
Processing of SMDT1
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Mitochondrial calcium ion transport
Processing of SMDT1
Transport of small molecules
Gene Ontology Terms (9)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (55)
1 – 10 of 55
PDCD1
Tclin
Novelty: 0.000448
p_int: 0.996571355
p_ni: 0.000696629
p_wrong: 0.002732017
Data Source: BioPlex
GPR183
Tchem
Family: GPCR
Novelty: 0.02005679
p_int: 0.996431458
p_ni: 0.000273908
p_wrong: 0.003294635
Score: 0.173
Data Source: BioPlex,STRINGDB
EID3
Tdark
Novelty: 0.37412011
p_int: 0.996265815
p_ni: 0.003188026
p_wrong: 0.000546159
Score: 0.232
Data Source: BioPlex,STRINGDB
ASPH
Tbio
Family: Enzyme
Novelty: 0.00291455
p_int: 0.9959214
p_ni: 0.000507468
p_wrong: 0.003571132
Score: 0.175
Data Source: BioPlex,STRINGDB
MYLK2
Tchem
Family: Kinase
Novelty: 0.0080273
p_int: 0.868192546
p_ni: 0.131806089
p_wrong: 0.000001366
Score: 0.313
Data Source: BioPlex,STRINGDB
MICU2
Tbio
Novelty: 0.04146208
Score: 0.978
Data Source: STRINGDB
MCU
Tbio
Family: IC
Novelty: 0.00114914
Score: 0.977
Data Source: STRINGDB
MICU3
Tbio
Novelty: 0.09752188
Score: 0.974
Data Source: STRINGDB
MCUB
Tbio
Novelty: 0.0486243
Score: 0.972
Data Source: STRINGDB
MICU1
Tbio
Novelty: 0.00984731
Score: 0.971
Data Source: STRINGDB
Publication Statistics
PubMed Score  31.47

PubMed score by year
PubTator Score  69.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer