You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HBG1
Hemoglobin subunit gamma-1

Protein Summary
Description
Gamma chains make up the fetal hemoglobin F, in combination with alpha chains. The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330597
  • ENSP00000327431
  • ENSG00000213934

Symbol
  • HBGA
  • HBGR
  • HBG-T2
  • HSGGL1
  • PRO2979
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.8
biological term
0.64
protein domain
0.58
molecular function
0.53
PubMedID
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 272.61   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 272.61   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (2)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Hemostasis
Gene Ontology Terms (12)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (54)
1 – 10 of 54
HBG2
Tbio
Novelty: 0.01145628
Score: 0.983
Data Source: STRINGDB
HBE1
Tbio
Novelty: 0.00125958
Score: 0.965
Data Source: STRINGDB
HBZ
Tbio
Novelty: 0.00331625
Score: 0.965
Data Source: STRINGDB
HBD
Tbio
Novelty: 0.00203187
Score: 0.963
Data Source: STRINGDB
NFE2
Tbio
Family: TF
Novelty: 0.00321017
Score: 0.957
Data Source: STRINGDB
HBB
Tbio
Novelty: 0.00049683
Score: 0.913
Data Source: STRINGDB
MAFF
Tbio
Family: TF
Novelty: 0.01974936
Score: 0.9
Data Source: STRINGDB
MAFK
Tbio
Family: TF
Novelty: 0.01735942
Score: 0.9
Data Source: STRINGDB
MAFG
Tbio
Family: TF
Novelty: 0.01605125
Score: 0.9
Data Source: STRINGDB
HBA1
Tclin
Novelty: 0.00094113
Score: 0.879
Data Source: STRINGDB
Publication Statistics
PubMed Score  272.61

PubMed score by year
PubTator Score  286.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer