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Tbio
BGN
Biglycan

Protein Summary
Description
May be involved in collagen fiber assembly. This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in bone growth, muscle development and regeneration, and collagen fibril assembly in multiple tissues. This protein may also regulate inflammation and innate immunity. Additionally, the encoded protein may contribute to atherosclerosis and aortic valve stenosis in human patients. This gene and the related gene decorin are thought to be the result of a gene duplication. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331595
  • ENSP00000327336
  • ENSG00000182492

Symbol
  • SLRR1A
  • PGI
  • MRLS
  • DSPG1
  • PG-S1
  • SEMDX
  • SLRR1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
disease perturbation
0.97
cellular component
0.89
small molecule perturbation
0.82
gene perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 717.88   (req: < 5)
Gene RIFs: 73   (req: <= 3)
Antibodies: 371   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 717.88   (req: >= 5)
Gene RIFs: 73   (req: > 3)
Antibodies: 371   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
1
1
89.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
89.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
biglycan
473829
Macaque
biglycan
697544
Mouse
MGI:88158
12111
Rat
RGD:2207
25181
Dog
biglycan
VGNC:38443
403905
Species
Name
OMA
EggNOG
Inparanoid
Chimp
biglycan
Macaque
biglycan
Mouse
Rat
Dog
biglycan
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P21810-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (22)
A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
A tetrasaccharide linker sequence is required for GAG synthesis
Reactome
CS/DS degradation
Reactome
Chondroitin sulfate biosynthesis
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Defective B3GALT6 causes EDSP2 and SEMDJL1
Name
Explore in Pharos
Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis
CS/DS degradation
Chondroitin sulfate biosynthesis
Chondroitin sulfate/dermatan sulfate metabolism
Defective B3GALT6 causes EDSP2 and SEMDJL1
Gene Ontology Terms (19)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (222)
1 – 10 of 222
VCAN
Tbio
Novelty: 0.00110986
Score: 0.985
Data Source: STRINGDB
TLR4
Tchem
Novelty: 0.00010863
Score: 0.981
Data Source: STRINGDB
HSPG2
Tbio
Family: Enzyme
Novelty: 0.00159541
Score: 0.977
Data Source: STRINGDB
TGFB1
Tchem
Novelty: 0.0001299
Score: 0.976
Data Source: Reactome,STRINGDB
GPC1
Tbio
Novelty: 0.00293087
Score: 0.956
Data Source: STRINGDB
BCAN
Tbio
Novelty: 0.00737982
Score: 0.955
Data Source: STRINGDB
TLR2
Tchem
Novelty: 0.00023242
Score: 0.955
Data Source: STRINGDB
SDC1
Tbio
Novelty: 0.00044792
Score: 0.953
Data Source: STRINGDB
AGRN
Tbio
Novelty: 0.00156441
Score: 0.951
Data Source: STRINGDB
SDC4
Tbio
Novelty: 0.00319073
Score: 0.949
Data Source: STRINGDB
Publication Statistics
PubMed Score  717.88

PubMed score by year
PubTator Score  588.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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