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Tbio
ATP13A2
Cation-transporting ATPase 13A2

Protein Summary
Description
ATPase that plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity (PubMed:22186024). Required for a proper lysosomal and mitochondrial maintenance (PubMed:22296644, PubMed:28137957). This gene encodes a member of the P5 subfamily of ATPases which transports inorganic cations as well as other substrates. Mutations in this gene are associated with Kufor-Rakeb syndrome (KRS), also referred to as Parkinson disease 9. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326735
  • ENSP00000327214
  • ENSG00000159363
  • ENST00000341676
  • ENSP00000341115
  • ENST00000452699
  • ENSP00000413307

Symbol
  • PARK9
  • CLN12
  • KRPPD
  • PARK9
  • SPG78
  • HSA9947
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
protein domain
0.92
histone modification site profile
0.82
kinase perturbation
0.76
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.71   (req: < 5)
Gene RIFs: 68   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.71   (req: >= 5)
Gene RIFs: 68   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (4)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Ion transport by P-type ATPases
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Ion transport by P-type ATPases
Transport of small molecules
Gene Ontology Terms (49)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (114)
1 – 10 of 114
HLA-DPA1
Tbio
Novelty: 0.01432663
p_int: 0.999927543
p_ni: 0.000072456
p_wrong: 2e-9
Score: 0.15
Data Source: BioPlex,STRINGDB
MCOLN3
Tchem
Family: IC
Novelty: 0.05172316
p_int: 0.999695385
p_ni: 0.000304615
Data Source: BioPlex
LRRC55
Tbio
Family: IC
Novelty: 0.37735849
p_int: 0.999649233
p_ni: 0.000350767
Data Source: BioPlex
TMED7
Tdark
Novelty: 0.57942602
p_int: 0.998632555
p_ni: 0.001367445
Data Source: BioPlex
PCDHA3
Tdark
Novelty: 2.54545455
p_int: 0.997856619
p_ni: 0.002143381
Data Source: BioPlex
PCDHGB2
Tdark
p_int: 0.997388849
p_ni: 0.002611151
Data Source: BioPlex
NKAIN1
Tdark
Family: Enzyme
Novelty: 0.60115607
p_int: 0.99663779
p_ni: 0.00336221
Data Source: BioPlex
PBXIP1
Tbio
Novelty: 0.15158351
p_int: 0.99456931
p_ni: 0.00543069
Data Source: BioPlex
SCN3B
Tbio
Family: IC
Novelty: 0.08995222
p_int: 0.98307024
p_ni: 0.01692976
Data Source: BioPlex
HAVCR2
Tbio
Novelty: 0.00217571
p_int: 0.978752388
p_ni: 0.021247535
p_wrong: 7.7e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  124.71

PubMed score by year
PubTator Score  111.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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