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Tbio
MIEF1
MIEF1 upstream open reading frame protein

Protein Summary
Description
Involved in the regulation of mitochondrial fission mediated by DNM1L (PubMed:29083303). Positively regulates mitochondrial translation (PubMed:30215512). May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits (Probable).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000637854
  • ENSP00000490747
  • ENSG00000100335

Symbol
  • MID51
  • SMCR7L
  • AltMIEF1
  • HSU79252
  • MIEF1-MP
  • dJ1104E15.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
drug perturbation
0.96
kinase perturbation
0.84
molecular function
0.84
microRNA
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.27   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.27   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (66)
1 – 10 of 66
FIS1
Tbio
Novelty: 0.00552092
Score: 0.931
Data Source: STRINGDB
MFF
Tbio
Novelty: 0.00473776
Score: 0.896
Data Source: STRINGDB
DNM1L
Tbio
Novelty: 0.00184129
Score: 0.843
Data Source: STRINGDB
MFN1
Tbio
Novelty: 0.00597509
Score: 0.77
Data Source: STRINGDB
MB21D2
Tdark
Novelty: 12
Score: 0.723
Data Source: STRINGDB
MFN2
Tbio
Novelty: 0.00067716
Score: 0.711
Data Source: STRINGDB
OPA1
Tbio
Novelty: 0.00217983
Score: 0.704
Data Source: STRINGDB
CHST12
Tbio
Family: Enzyme
Novelty: 0.07210463
Score: 0.675
Data Source: STRINGDB
ITPRIPL2
Tdark
Novelty: 6
Score: 0.658
Data Source: STRINGDB
TOMM20
Tbio
Novelty: 0.00600801
Score: 0.658
Data Source: STRINGDB
Publication Statistics
PubMed Score  14.27

PubMed score by year
PubTator Score  11.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MAPWSREAVLSLYRALLRQGRQLRYTDRDFYFASIRREFRKNQKLEDAEARERQLEKGLVFLNGKLGRII
1-70
MAPWSREAVLSLYRALLRQGRQLRYTDRDFYFASIRREFRKNQKLEDAEARERQLEKGLVFLNGKLGRII