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Tbio
FTSJ1
Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase

Protein Summary
Description
Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. This gene encodes a member of the methyltransferase superfamily. The encoded protein localizes to the nucleolus, binds to S-adenosylmethionine, and may be involved in the processing and modification of ribosomal RNA. Mutations in this gene are associated with cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000019019
  • ENSP00000019019
  • ENSG00000068438
  • ENST00000348411
  • ENSP00000326948

Symbol
  • JM23
  • MRX9
  • SPB1
  • CDLIV
  • MRX44
  • TRMT7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
disease perturbation
0.87
histone modification site profile
0.68
virus perturbation
0.68
cell type or tissue
0.66


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.26   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.26   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
FtsJ RNA methyltransferase homolog 1
710243
Mouse
MGI:1859648
54632
Rat
RGD:1561061
363450
Dog
FtsJ RNA methyltransferase homolog 1
VGNC:49604
480902
Horse
FtsJ RNA methyltransferase homolog 1
VGNC:50479
100061804
Species
Name
OMA
EggNOG
Inparanoid
Macaque
FtsJ RNA methyltransferase homolog 1
Mouse
Rat
Dog
FtsJ RNA methyltransferase homolog 1
Horse
FtsJ RNA methyltransferase homolog 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UET6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the nucleus and cytosol
tRNA processing
Protein-Protein Interactions (197)
1 – 10 of 197
CHRM3
Tclin
Family: GPCR
Novelty: 0.00849776
p_int: 0.879215924
p_ni: 0.120784076
Score: 0.224
Data Source: BioPlex,STRINGDB
WDR6
Tbio
Novelty: 0.20146637
Score: 0.956
Data Source: STRINGDB
NSUN2
Tbio
Family: Enzyme
Novelty: 0.01546947
Score: 0.92
Data Source: STRINGDB
THADA
Tbio
Novelty: 0.06983966
Score: 0.919
Data Source: STRINGDB
TRMT1
Tbio
Family: Enzyme
Novelty: 0.01795504
Score: 0.916
Data Source: STRINGDB
TRMT6
Tbio
Family: Enzyme
Novelty: 0.06718902
Score: 0.915
Data Source: STRINGDB
WDR12
Tbio
Novelty: 0.03409059
Score: 0.901
Data Source: STRINGDB
NIP7
Tbio
Novelty: 0.05885055
Score: 0.884
Data Source: STRINGDB
TRMT11
Tbio
Family: Enzyme
Novelty: 0.11506701
Score: 0.884
Data Source: STRINGDB
WDR4
Tbio
Family: Enzyme
Novelty: 0.06887397
Score: 0.873
Data Source: STRINGDB
Publication Statistics
PubMed Score  70.26

PubMed score by year
PubTator Score  14.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer