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Tbio
SERTAD2
SERTA domain-containing protein 2

Protein Summary
Description
Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313349
  • ENSP00000326933
  • ENSG00000179833

Symbol
  • KIAA0127
  • TRIPBR2
  • Sei-2
  • TRIPBR2
  • TRIP-Br2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
kinase perturbation
0.97
transcription factor binding site profile
0.95
transcription factor perturbation
0.88
microRNA
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.75   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.75   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
2
6
99.4
testosterone measurement
3
2
3
97.7
mean corpuscular hemoglobin concentration
1
1
1
79.7
red blood cell distribution width
3
1
3
77.1
heel bone mineral density
2
1
2
72.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
99.4
testosterone measurement
3
97.7
mean corpuscular hemoglobin concentration
1
79.7
red blood cell distribution width
3
77.1
heel bone mineral density
2
72.3
Pathways (16)
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Nuclear Receptors Meta-Pathway
WikiPathways
Nuclear Receptors Meta-Pathway
WikiPathways
Nuclear Receptors Meta-Pathway
WikiPathways
Nuclear Receptors Meta-Pathway
WikiPathways
Nuclear Receptors Meta-Pathway
Name
Explore in Pharos
Explore in Source
Nuclear Receptors Meta-Pathway
Nuclear Receptors Meta-Pathway
Nuclear Receptors Meta-Pathway
Nuclear Receptors Meta-Pathway
Nuclear Receptors Meta-Pathway
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (23)
1 – 10 of 23
DZIP1L
Tdark
Novelty: 0.13394475
Score: 0.709
Data Source: STRINGDB
SERTAD3
Tbio
Novelty: 0.07024588
Score: 0.671
Data Source: STRINGDB
DCAF1
Tbio
Novelty: 0.0170232
Score: 0.587
Data Source: STRINGDB
LRRC8C
Tbio
Novelty: 0.11920205
Score: 0.585
Data Source: STRINGDB
LRRC8B
Tbio
Novelty: 0.16457267
Score: 0.584
Data Source: STRINGDB
KAT5
Tchem
Family: Epigenetic
Novelty: 0.00368348
Score: 0.559
Data Source: STRINGDB
AFTPH
Tbio
Novelty: 0.21887849
Score: 0.556
Data Source: STRINGDB
PANX3
Tbio
Family: IC
Novelty: 0.0071997
Score: 0.549
Data Source: STRINGDB
SUPT7L
Tdark
Novelty: 0.20661559
Score: 0.541
Data Source: STRINGDB
CEP68
Tbio
Novelty: 0.42645916
Score: 0.527
Data Source: STRINGDB
Publication Statistics
PubMed Score  14.75

PubMed score by year
PubTator Score  6.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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