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Tbio
ZFPM1
Zinc finger protein ZFPM1

Protein Summary
Description
Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319555
  • ENSP00000326630
  • ENSG00000179588

Symbol
  • FOG1
  • ZFN89A
  • FOG
  • FOG1
  • ZNF408
  • ZNF89A
  • ZC2HC11A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
transcription factor perturbation
0.91
transcription factor binding site profile
0.88
molecular function
0.7
transcription factor
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.3   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.3   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
2
3
97.4
low density lipoprotein cholesterol measurement
5
4
5
94.2
C-reactive protein measurement
1
1
1
90
eosinophil count
3
2
3
88.4
basophil count
2
2
2
75.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
97.4
low density lipoprotein cholesterol measurement
5
94.2
C-reactive protein measurement
1
90
eosinophil count
3
88.4
basophil count
2
75.9
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (9)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Hemostasis
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Gene expression (Transcription)
Generic Transcription Pathway
Hemostasis
RNA Polymerase II Transcription
Gene Ontology Terms (40)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Genetic Interaction (IGI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (114)
1 – 10 of 114
ERP44
Tbio
Novelty: 0.02352693
p_int: 0.999999982
p_ni: 1.6e-8
p_wrong: 1e-9
Score: 0.222
Data Source: BioPlex,STRINGDB
DEFA6
Tbio
Novelty: 0.0363171
p_int: 0.999999895
p_ni: 1.03e-7
p_wrong: 2e-9
Score: 0.214
Data Source: BioPlex,STRINGDB
GATA2
Tbio
Family: TF
Novelty: 0.00153967
p_int: 0.999998747
p_ni: 0.000001025
p_wrong: 2.27e-7
Score: 0.986
Data Source: BioPlex,STRINGDB
GATA1
Tbio
Family: TF
Novelty: 0.00077901
Score: 0.995
Data Source: Reactome,STRINGDB
RBBP4
Tbio
Novelty: 0.01062843
Score: 0.961
Data Source: STRINGDB
GATA4
Tbio
Family: TF
Novelty: 0.00094282
Score: 0.951
Data Source: STRINGDB
GATA6
Tbio
Family: TF
Novelty: 0.00267511
Score: 0.946
Data Source: STRINGDB
GATA3
Tbio
Family: TF
Novelty: 0.00071141
Score: 0.945
Data Source: STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
Score: 0.944
Data Source: STRINGDB
RBBP7
Tbio
Novelty: 0.01795364
Score: 0.942
Data Source: STRINGDB
Publication Statistics
PubMed Score  92.30

PubMed score by year
PubTator Score  1128.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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