Tdark ABHD1 Protein ABHD1

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Protein Abhd1

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Protein Abhd1

Protein Summary

Description

This gene is a member of the AB hydrolase superfamily and encodes a protein with an alpha/beta hydrolase fold. This domain is common to a number of hydrolytic enzymes of widely differing phylogenetic origins and catalytic functions. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96SE0
• B3KSF6
• E9PDR9
• Q05BY3
• Q53SZ1
• Q8IXQ7

Gene Name

• ABHD1

Ensembl ID

• ENST00000316470
• ENSP00000326491
• ENSG00000143994
• ENST00000448950
• ENSP00000410756
• ENST00000621324
• ENSP00000481238

Symbol

• LABH1
• LABH1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.8
tissue sample	0.66
cell line	0.47
tissue	0.43
cell type or tissue	0.41

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.64   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 125   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.64   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Gene Ontology Terms (7)

Functions (3)

Components (1)

Processes (3)

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
acylglycerol lipase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
lipase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
short-chain carboxylesterase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (44)

Explore Interacting Targets

1 – 10 of 44

• See Interactions on String-DB

PREB

Tbio

Family: TF

Novelty: 0.00430442

Score: 0.71

Data Source: STRINGDB

OSBPL1A

Tbio

Novelty: 0.17271249

Score: 0.661

Data Source: STRINGDB

ENDOD1

Tdark

Family: Enzyme

Novelty: 0.23953959

Score: 0.658

Data Source: STRINGDB

FGF19

Tbio

Novelty: 0.0025092

Score: 0.649

Data Source: STRINGDB

SNTG1

Tbio

Novelty: 0.03490951

Score: 0.581

Data Source: STRINGDB

CABLES2

Tdark

Novelty: 1.28395062

Score: 0.576

Data Source: STRINGDB

CABLES1

Tbio

Novelty: 0.01097728

Score: 0.576

Data Source: STRINGDB

TEX38

Tdark

Score: 0.53

Data Source: STRINGDB

FAM166A

Tdark

Score: 0.514

Data Source: STRINGDB

KIRREL1

Tbio

Novelty: 0.03852239

Score: 0.508

Data Source: STRINGDB

Publication Statistics

PubMed Score  1.64

PubMed score by year

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PubTator Score  0.5

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MLSSFLSPQNGTWADTFSLLLALAVALYLGYYWACVLQRPRLVAGPQFLAFLEPHCSITTETFYPTLWCF

1-70

EGRLQSIFQVLLQSQPLVLYQSDILQTPDGGQLLLDWAKQPDSSQDPDPTTQPIVLLLPGITGSSQDTYV

70-140

LHLVNQALRDGYQAVVFNNRGCRGEELRTHRAFCASNTEDLETVVNHIKHRYPQAPLLAVGISFGGILVL

140-210

NHLAQARQAAGLVAALTLSACWDSFETTRSLETPLNSLLFNQPLTAGLCQLVERNRKVIEKVVDIDFVLQ

210-280

ARTIRQFDERYTSVAFGYQDCVTYYKAASPRTKIDAIRIPVLYLSAADDPFSPVCALPIQAAQHSPYVAL

280-350

LITARGGHIGFLEGLLPWQHWYMSRLLHQYAKAIFQDPEGLPDLRALLPSEDRNS

350-405

MLSSFLSPQNGTWADTFSLLLALAVALYLGYYWACVLQRPRLVAGPQFLAFLEPHCSITTETFYPTLWCFEGRLQSIFQVLLQSQPLVLYQSDILQTPDGGQLLLDWAKQPDSSQDPDPTTQPIVLLLPGITGSSQDTYVLHLVNQALRDGYQAVVFNNRGCRGEELRTHRAFCASNTEDLETVVNHIKHRYPQAPLLAVGISFGGILVLNHLAQARQAAGLVAALTLSACWDSFETTRSLETPLNSLLFNQPLTAGLCQLVERNRKVIEKVVDIDFVLQARTIRQFDERYTSVAFGYQDCVTYYKAASPRTKIDAIRIPVLYLSAADDPFSPVCALPIQAAQHSPYVALLITARGGHIGFLEGLLPWQHWYMSRLLHQYAKAIFQDPEGLPDLRALLPSEDRNS

Find similar targets by:

Uniprot Keyword

Alternative splicing
Complete proteome
Glycoprotein
Hydrolase
Membrane
Polymorphism
Reference proteome
Serine esterase
Signal-anchor
Transmembrane