Tbio MYNN Myoneurin

Protein Summary

Description

This gene encodes a member of the BTB/POZ and zinc finger domain-containing protein family that are involved in the control of gene expression. Alternative splicing results in multiple transcript variants and a pseudogene has been identified on chromosome 14. [provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• Q9NPC7
• B2R6C9
• Q6QHA6
• Q6QHA7
• Q6R3G1
• Q6R3G2
• Q6R4A0
• Q7Z716
• Q7Z717
• Q86Z11
• Q86Z12
• Q9NS01
• Q9UIW8

Gene Name

• MYNN

Ensembl ID

• ENST00000349841
• ENSP00000326240
• ENSG00000085274
• ENST00000356716
• ENSP00000349150
• ENST00000544106
• ENSP00000440637
• ENST00000602751
• ENSP00000473654

Symbol

• OSZF
• ZBTB31
• OSZF
• SBBIZ1
• ZBTB31
• ZNF902

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
transcription factor binding site profile	0.97
transcription factor perturbation	0.97
protein domain	0.85
phenotype	0.84

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.55   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 221   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.55   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Gene Ontology Terms (7)

Functions (4)

Components (1)

Processes (2)

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
DNA-binding transcription factor activity	Traceable Author Statement (TAS)	ProtInc
zinc ion binding	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (35)

Explore Interacting Targets

1 – 10 of 35

• See Interactions on String-DB

RHPN2

Tbio

Novelty: 0.10708139

Score: 0.743

Data Source: STRINGDB

ACTRT3

Tdark

Novelty: 0.88888889

Score: 0.704

Data Source: STRINGDB

LRRIQ4

Tdark

Novelty: 7

Score: 0.679

Data Source: STRINGDB

LRRC34

Tdark

Novelty: 0.37037037

Score: 0.671

Data Source: STRINGDB

ZNF800

Tdark

Family: TF

Novelty: 4

Score: 0.597

Data Source: STRINGDB

CSRNP2

Tdark

Novelty: 1.32352941

Score: 0.565

Data Source: STRINGDB

NCKAP5L

Tdark

Novelty: 0.59800664

Score: 0.544

Data Source: STRINGDB

LRRC31

Tdark

Novelty: 1.81818182

Score: 0.542

Data Source: STRINGDB

POC1B

Tbio

Novelty: 0.11982426

Score: 0.541

Data Source: STRINGDB

TMBIM4

Tbio

Novelty: 0.01198169

Score: 0.531

Data Source: STRINGDB

Publication Statistics

PubMed Score  12.55

PubMed score by year

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PubTator Score  3.55

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MQYSHHCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAIYRSTSENNVFLDQSQVKA

1-70

DGFQKLLEFIYTGTLNLDSWNVKEIHQAADYLKVEEVVTKCKIKMEDFAFIANPSSTEISSITGNIELNQ

70-140

QTCLLTLRDYNNREKSEVSTDLIQANPKQGALAKKSSQTKKKKKAFNSPKTGQNKTVQYPSDILENASVE

140-210

LFLDANKLPTPVVEQVAQINDNSELELTSVVENTFPAQDIVHTVTVKRKRGKSQPNCALKEHSMSNIASV

210-280

KSPYEAENSGEELDQRYSKAKPMCNTCGKVFSEASSLRRHMRIHKGVKPYVCHLCGKAFTQCNQLKTHVR

280-350

THTGEKPYKCELCDKGFAQKCQLVFHSRMHHGEEKPYKCDVCNLQFATSSNLKIHARKHSGEKPYVCDRC

350-420

GQRFAQASTLTYHVRRHTGEKPYVCDTCGKAFAVSSSLITHSRKHTGEKPYICGICGKSFISSGELNKHF

420-490

RSHTGERPFICELCGNSYTDIKNLKKHKTKVHSGADKTLDSSAEDHTLSEQDSIQKSPLSETMDVKPSDM

490-560

TLPLALPLGTEDHHMLLPVTDTQSPTSDTLLRSTVNGYSEPQLIFLQQLY

560-610

MQYSHHCEHLLERLNKQREAGFLCDCTIVIGEFQFKAHRNVLASFSEYFGAIYRSTSENNVFLDQSQVKADGFQKLLEFIYTGTLNLDSWNVKEIHQAADYLKVEEVVTKCKIKMEDFAFIANPSSTEISSITGNIELNQQTCLLTLRDYNNREKSEVSTDLIQANPKQGALAKKSSQTKKKKKAFNSPKTGQNKTVQYPSDILENASVELFLDANKLPTPVVEQVAQINDNSELELTSVVENTFPAQDIVHTVTVKRKRGKSQPNCALKEHSMSNIASVKSPYEAENSGEELDQRYSKAKPMCNTCGKVFSEASSLRRHMRIHKGVKPYVCHLCGKAFTQCNQLKTHVRTHTGEKPYKCELCDKGFAQKCQLVFHSRMHHGEEKPYKCDVCNLQFATSSNLKIHARKHSGEKPYVCDRCGQRFAQASTLTYHVRRHTGEKPYVCDTCGKAFAVSSSLITHSRKHTGEKPYICGICGKSFISSGELNKHFRSHTGERPFICELCGNSYTDIKNLKKHKTKVHSGADKTLDSSAEDHTLSEQDSIQKSPLSETMDVKPSDMTLPLALPLGTEDHHMLLPVTDTQSPTSDTLLRSTVNGYSEPQLIFLQQLY

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Uniprot Keyword

3D-structure
Alternative splicing
Complete proteome
DNA-binding
Metal-binding
Nucleus
Phosphoprotein
Reference proteome
Repeat
Transcription