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Tclin
PGR
Progesterone receptor

Protein Summary
Description
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor. Isoform A: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2. Isoform B: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone. This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263463
  • ENSP00000263463
  • ENSG00000082175
  • ENST00000325455
  • ENSP00000325120
  • ENST00000534013
  • ENSP00000436561

Symbol
  • NR3C3
  • PR
  • NR3C3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
molecular function
0.99
biological term
0.97
disease
0.89
drug
0.85


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10187.28   (req: < 5)
Gene RIFs: 570   (req: <= 3)
Antibodies: 2677   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10187.28   (req: >= 5)
Gene RIFs: 570   (req: > 3)
Antibodies: 2677   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 607
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 24
Approved Drugs (24)
1 – 10 of 24
progesterone
chemical structure image
fulvestrant
chemical structure image
medroxyprogesterone
chemical structure image
mifepristone
chemical structure image
danazol
chemical structure image
hydroxyprogesterone caproate
chemical structure image
norgestimate
chemical structure image
norethindrone acetate
chemical structure image
fluticasone propionate
chemical structure image
budesonide
chemical structure image
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
progesterone receptor
VGNC:11682
451502
Macaque
progesterone receptor
613024
Mouse
MGI:97567
18667
Rat
RGD:3317
25154
Dog
progesterone receptor
VGNC:44469
403621
Species
Name
OMA
EggNOG
Inparanoid
Chimp
progesterone receptor
Macaque
progesterone receptor
Mouse
Rat
Dog
progesterone receptor
Protein Data Bank (20)
1 – 5 of 20
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (30)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
ESR-mediated signaling
Estrogen-dependent gene expression
Gene expression (Transcription)
Gene Ontology Terms (27)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (299)
1 – 10 of 299
HSP90AA1
Tchem
Novelty: 0.00016774
Score: 0.985
Data Source: STRINGDB
FKBP4
Tchem
Family: Enzyme
Novelty: 0.0023525
Score: 0.973
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.973
Data Source: STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
Score: 0.972
Data Source: STRINGDB
ESR1
Tclin
Family: NR
Novelty: 0.00005938
Score: 0.964
Data Source: Reactome,STRINGDB
FKBP5
Tchem
Family: Enzyme
Novelty: 0.00214511
Score: 0.963
Data Source: STRINGDB
NCOA3
Tbio
Family: Epigenetic
Novelty: 0.00193529
Score: 0.961
Data Source: STRINGDB
FOXA1
Tbio
Family: TF
Novelty: 0.00235269
Score: 0.96
Data Source: STRINGDB
GATA3
Tbio
Family: TF
Novelty: 0.00071141
Score: 0.957
Data Source: STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00061058
Score: 0.957
Data Source: STRINGDB
Publication Statistics
PubMed Score  10187.28

PubMed score by year
PubTator Score  5940.4

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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