You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CABP4
Calcium-binding protein 4

Protein Summary
Description
Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages (By similarity). This gene encodes a member of the CABP family of calcium binding protein characterized by four EF-hand motifs. Mutations in this gene are associated with congenital stationary night blindness type 2B. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325656
  • ENSP00000324960
  • ENSG00000175544
  • ENST00000438189
  • ENSP00000401555

Symbol
  • CRSD
  • CSNB2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.66
cell line
0.64
cellular component
0.53
PubMedID
0.53
microRNA
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.29   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.29   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
36.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
36.5
Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (75)
1 – 10 of 75
CACNA1F
Tchem
Family: IC
Novelty: 0.00431963
Score: 0.903
Data Source: STRINGDB
NYX
Tbio
Novelty: 0.0100148
Score: 0.718
Data Source: STRINGDB
CACNA1D
Tclin
Family: IC
Novelty: 0.00314752
Score: 0.698
Data Source: STRINGDB
GPR179
Tdark
Family: GPCR
Novelty: 0.09278403
Score: 0.698
Data Source: STRINGDB
LRIT3
Tbio
Novelty: 0.2385612
Score: 0.689
Data Source: STRINGDB
CACNA2D4
Tbio
Family: IC
Novelty: 0.02238343
Score: 0.688
Data Source: STRINGDB
GRM6
Tchem
Family: GPCR
Novelty: 0.00681104
Score: 0.654
Data Source: STRINGDB
MYH10
Tbio
Novelty: 0.00624251
Score: 0.634
Data Source: STRINGDB
SPATA7
Tbio
Novelty: 0.07689485
Score: 0.633
Data Source: STRINGDB
IQCB1
Tbio
Novelty: 0.02979098
Score: 0.629
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.29

PubMed score by year
PubTator Score  15.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer