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Tbio
PPP2R1A
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

Protein Summary
Description
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (PubMed:15525651). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (PubMed:16580887). This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322088
  • ENSP00000324804
  • ENSG00000105568

Symbol
  • MRD36
  • PP2AA
  • PR65A
  • PP2AAALPHA
  • PP2A-Aalpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
biological process
0.98
co-expressed gene
0.98
disease perturbation
0.96
interacting protein
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.61   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 359   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.61   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 359   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (15)
1 – 5 of 15
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (165)
AMER1 mutants destabilize the destruction complex (R-HSA-4839748)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 137
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AMER1 mutants destabilize the destruction complex
Reactome
APC truncation mutants have impaired AXIN binding
Reactome
AURKA Activation by TPX2
Reactome
AXIN missense mutants destabilize the destruction complex
Reactome
AXIN mutants destabilize the destruction complex, activating WNT signaling
Name
Explore in Pharos
Explore in Source
AMER1 mutants destabilize the destruction complex
APC truncation mutants have impaired AXIN binding
AURKA Activation by TPX2
AXIN missense mutants destabilize the destruction complex
AXIN mutants destabilize the destruction complex, activating WNT signaling
Gene Ontology Terms (44)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (703)
1 – 10 of 703
PPP2R5B
Tbio
Family: Enzyme
Novelty: 0.08980945
p_int: 0.99999999
p_ni: 1e-8
Score: 0.997
Data Source: BioPlex,STRINGDB
PPP2R5D
Tbio
Family: Enzyme
Novelty: 0.03990599
p_int: 0.999999944
p_ni: 5.6e-8
Score: 0.998
Data Source: BioPlex,STRINGDB
PPP2R5A
Tchem
Family: Enzyme
Novelty: 0.03073487
p_int: 0.99999987
p_ni: 1.3e-7
Score: 0.998
Data Source: BioPlex,STRINGDB
PPP2R3B
Tbio
Family: Enzyme
Novelty: 0.02932064
p_int: 0.999999747
p_ni: 2.53e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
ANKLE2
Tbio
Novelty: 0.0995907
p_int: 0.999999538
p_ni: 4.45e-7
p_wrong: 1.7e-8
Score: 0.392
Data Source: BioPlex,STRINGDB
PPP2R1B
Tbio
Family: Enzyme
Novelty: 0.03936638
p_int: 0.999999503
p_ni: 4.97e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
PPP2CA
Tchem
Family: Enzyme
Novelty: 0.00496839
p_int: 0.999997661
p_ni: 0.000002339
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
PPFIA3
Tbio
Novelty: 0.03837299
p_int: 0.999997639
p_ni: 0.00000236
Score: 0.483
Data Source: BioPlex,STRINGDB
PPP2R3C
Tbio
Family: Enzyme
Novelty: 0.02970644
p_int: 0.999995933
p_ni: 0.00000403
p_wrong: 3.7e-8
Score: 0.703
Data Source: BioPlex,STRINGDB
PPP2R5E
Tbio
Family: Enzyme
Novelty: 0.05974697
p_int: 0.999995711
p_ni: 0.000004288
Score: 0.998
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  70.61

PubMed score by year
PubTator Score  34.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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