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Tbio
GRHL1
Grainyhead-like protein 1 homolog

Protein Summary
Description
Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' (PubMed:12175488, PubMed:18288204, PubMed:29309642). Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity). Isoform 1: Functions as transcription activator. Isoform 2: May function as a repressor in tissues where both isoform 1 and isoform 2 are expressed. This gene encodes a member of the grainyhead family of transcription factors. The encoded protein can exist as a homodimer or can form heterodimers with sister-of-mammalian grainyhead or brother-of-mammalian grainyhead. This protein functions as a transcription factor during development. [provided by RefSeq, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324907
  • ENSP00000324693
  • ENSG00000134317
  • ENST00000405379
  • ENSP00000384209
  • ENST00000472167
  • ENSP00000418275

Symbol
  • LBP32
  • MGR
  • TFCP2L2
  • MGR
  • NH32
  • LBP32
  • TFCP2L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
molecular function
0.86
histone modification site profile
0.7
biological process
0.6
cellular component
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.76   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.76   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood urea nitrogen measurement
1
1
1
27.9
prostate carcinoma
1
1
0
1.1
20.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood urea nitrogen measurement
1
27.9
prostate carcinoma
0
1.1
20.1
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PPARA activates gene expression
Reactome
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PPARA activates gene expression
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Gene Ontology Terms (21)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (49)
1 – 10 of 49
GRHL2
Tbio
Family: TF
Novelty: 0.01092611
p_int: 0.999999644
p_ni: 2.52e-7
p_wrong: 1.04e-7
Score: 0.714
Data Source: BioPlex,STRINGDB
ZNF76
Tbio
Family: TF
Novelty: 0.22129218
p_int: 0.999998833
p_ni: 4.73e-7
p_wrong: 6.94e-7
Score: 0.685
Data Source: BioPlex,STRINGDB
RXRA
Tclin
Family: NR
Novelty: 0.00244343
Score: 0.907
Data Source: STRINGDB
CARM1
Tchem
Family: Epigenetic
Novelty: 0.00623937
Score: 0.904
Data Source: STRINGDB
CREBBP
Tchem
Family: Epigenetic
Novelty: 0.00111166
Score: 0.903
Data Source: STRINGDB
MED1
Tbio
Family: Enzyme
Novelty: 0.00852082
Score: 0.901
Data Source: STRINGDB
NCOA6
Tbio
Novelty: 0.00750424
Score: 0.9
Data Source: STRINGDB
TBL1XR1
Tbio
Novelty: 0.00503043
Score: 0.9
Data Source: STRINGDB
TBL1X
Tbio
Novelty: 0.00027212
Score: 0.9
Data Source: STRINGDB
NCOA2
Tbio
Novelty: 0.00510052
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  40.76

PubMed score by year
PubTator Score  22.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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