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Tbio
PLEC
Plectin

Protein Summary
Description
Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (reviewed in PMID: 9701547, 11854008, and 17499243). Ple ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322810
  • ENSP00000323856
  • ENSG00000178209
  • ENST00000345136
  • ENSP00000344848
  • ENST00000354589
  • ENSP00000346602
  • ENST00000354958
  • ENSP00000347044
  • ENST00000356346
  • ENSP00000348702
  • ENST00000357649
  • ENSP00000350277
  • ENST00000398774
  • ENSP00000381756
  • ENST00000436759
  • ENSP00000388180
  • ENST00000527096
  • ENSP00000434583

Symbol
  • PLEC1
  • HD1
  • PCN
  • EBS1
  • EBSO
  • PLTN
  • EBSMD
  • EBSND
  • EBSOG
  • EBSPA
  • PLEC1
  • LGMD2Q
  • PLEC1b
  • LGMDR17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
ligand (protein) perturbation
0.99
drug perturbation
0.96
transcription factor binding site profile
0.96
transcription factor perturbation
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 467.82   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 467.82   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
2
3
93
low density lipoprotein cholesterol measurement
6
5
7
90.7
platelet count
3
2
2
2.3
90.6
mean platelet volume
2
1
2
83.4
total cholesterol measurement
3
3
3
76.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
93
low density lipoprotein cholesterol measurement
7
90.7
platelet count
2
2.3
90.6
mean platelet volume
2
83.4
total cholesterol measurement
3
76.3
Protein Data Bank (14)
1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (18)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Caspase-mediated cleavage of cytoskeletal proteins
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Assembly of collagen fibrils and other multimeric structures
Caspase-mediated cleavage of cytoskeletal proteins
Gene Ontology Terms (23)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (381)
1 – 10 of 381
C6orf141
Tdark
Novelty: 1.46022784
p_int: 0.999985129
p_ni: 0.000014871
Data Source: BioPlex
GSDME
Tbio
Novelty: 0.01231123
p_int: 0.994392417
p_ni: 0.005607583
Score: 0.167
Data Source: BioPlex,STRINGDB
CCDC68
Tbio
Novelty: 0.1262502
p_int: 0.992687381
p_ni: 0.007312619
Score: 0.201
Data Source: BioPlex,STRINGDB
NEFM
Tbio
Novelty: 0.00239134
p_int: 0.991598474
p_ni: 0.008401526
Score: 0.305
Data Source: BioPlex,STRINGDB
RAPGEF5
Tbio
Novelty: 0.02449802
p_int: 0.985649193
p_ni: 0.014350807
Data Source: BioPlex
GFOD1
Tdark
Family: Enzyme
Novelty: 0.35031766
p_int: 0.957384589
p_ni: 0.042615411
Score: 0.166
Data Source: BioPlex,STRINGDB
FAM24B
Tdark
Novelty: 1.04675689
p_int: 0.93225298
p_ni: 0.06774702
Data Source: BioPlex
SOCS6
Tbio
Novelty: 0.00993375
p_int: 0.887467941
p_ni: 0.112532058
Score: 0.193
Data Source: BioPlex,STRINGDB
TFDP3
Tbio
Family: TF
Novelty: 0.00223003
p_int: 0.879869728
p_ni: 0.120130272
Score: 0.195
Data Source: BioPlex,STRINGDB
PRUNE1
Tchem
Novelty: 0.02136836
p_int: 0.867573742
p_ni: 0.132426258
Data Source: BioPlex
Publication Statistics
PubMed Score  467.82

PubMed score by year
PubTator Score  262.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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