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Tclin
HBA1
Hemoglobin subunit alpha

Protein Summary
Description
Involved in oxygen transport from the lung to the various peripheral tissues. The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251595
  • ENSP00000251595
  • ENSG00000188536
  • ENST00000320868
  • ENSP00000322421
  • ENSG00000206172

Symbol
  • HBH
  • ECYT7
  • HBA-T3
  • METHBA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
1
cellular component
0.99
interacting protein
0.96
biological term
0.85
cell type or tissue
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 942.33   (req: < 5)
Gene RIFs: 239   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 942.33   (req: >= 5)
Gene RIFs: 239   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
voxelotor
chemical structure image
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin A1 measurement
1
1
1
61.9
reticulocyte measurement
2
1
2
46.1
reticulocyte count
2
1
2
40
hemoglobin measurement
1
1
1
2.8
mean corpuscular hemoglobin
1
1
1
2.8
Items per page:
1 – 5 of 5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin A1 measurement
1
61.9
reticulocyte measurement
2
46.1
reticulocyte count
2
40
hemoglobin measurement
1
2.8
mean corpuscular hemoglobin
1
2.8
Protein Data Bank (260)
1 – 5 of 260
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Erythrocytes take up carbon dioxide and release oxygen
Reactome
Erythrocytes take up oxygen and release carbon dioxide
Reactome
O2/CO2 exchange in erythrocytes
Reactome
Scavenging of heme from plasma
Name
Explore in Pharos
Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors
Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
O2/CO2 exchange in erythrocytes
Scavenging of heme from plasma
Gene Ontology Terms (23)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (127)
1 – 10 of 127
UPF3A
Tbio
Novelty: 0.01431609
p_int: 0.999991122
p_ni: 0.000008878
Data Source: BioPlex
GDPD1
Tbio
Family: Enzyme
Novelty: 0.28722153
p_int: 0.999963934
p_ni: 0.000036066
Data Source: BioPlex
HLA-DPA1
Tbio
Novelty: 0.01080446
p_int: 0.999120943
p_ni: 0.000879057
Data Source: BioPlex
MAPK6
Tbio
Family: Kinase
Novelty: 0.01012514
p_int: 0.998292985
p_ni: 0.00170691
p_wrong: 1.05e-7
Data Source: BioPlex
TNFSF8
Tbio
Novelty: 0.01292216
p_int: 0.997937592
p_ni: 0.002062354
p_wrong: 5.4e-8
Data Source: BioPlex
MANSC1
Tdark
Novelty: 0.91681036
p_int: 0.997413917
p_ni: 0.002586083
Data Source: BioPlex
FCGR1A
Tchem
Novelty: 0.00073204
p_int: 0.995277328
p_ni: 0.004722661
p_wrong: 1.2e-8
Data Source: BioPlex
IGSF8
Tbio
Novelty: 0.03016623
p_int: 0.994241471
p_ni: 0.00575843
p_wrong: 9.9e-8
Data Source: BioPlex
MSL2
Tbio
Family: Enzyme
Novelty: 0.01221658
p_int: 0.991115363
p_ni: 0.008884633
p_wrong: 4e-9
Data Source: BioPlex
HSPA8
Tchem
Novelty: 0.00081014
p_int: 0.985787962
p_ni: 0.014212036
p_wrong: 2e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  942.33

PubMed score by year
PubTator Score  7445.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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