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Tbio
FAM20C
Extracellular serine/threonine protein kinase FAM20C

Protein Summary
Description
Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth (PubMed:22582013, PubMed:23754375, PubMed:25789606). Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome (PubMed:26091039). Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity (PubMed:26091039). Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1 (PubMed:22582013, PubMed:25789606). In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion (PubMed:26091039). This gene encodes a member of the family of secreted protein kinases. The encoded protein binds calcium and phosphorylates proteins involved in bone mineralization. Mutations in this gene a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313766
  • ENSP00000322323
  • ENSG00000177706

Symbol
  • DMP4
  • RNS
  • DMP4
  • G-CK
  • DMP-4
  • GEF-CK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
cell type or tissue
0.72
gene perturbation
0.66
small molecule perturbation
0.66
tissue sample
0.66


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 319.16   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 319.16   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2136853
80752
Rat
RGD:1311980
304334
Dog
FAM20C, golgi associated secretory pathway kinase
VGNC:40656
491596
Horse
FAM20C, golgi associated secretory pathway kinase
VGNC:17850
100056828
Cow
FAM20C, golgi associated secretory pathway kinase
VGNC:28787
534672
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
FAM20C, golgi associated secretory pathway kinase
Horse
FAM20C, golgi associated secretory pathway kinase
Cow
FAM20C, golgi associated secretory pathway kinase
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q8IXL6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Gene Ontology Terms (22)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (141)
1 – 10 of 141
FAM20A
Tbio
Family: Enzyme
Novelty: 0.03742119
Score: 0.988
Data Source: Reactome,STRINGDB
ENAM
Tbio
Novelty: 0.00593293
Score: 0.985
Data Source: STRINGDB
FGF23
Tclin
Novelty: 0.00047318
Score: 0.983
Data Source: STRINGDB
SPP1
Tbio
Novelty: 0.00014418
Score: 0.975
Data Source: STRINGDB
AMELX
Tbio
Novelty: 0.00063284
Score: 0.974
Data Source: STRINGDB
DMP1
Tbio
Novelty: 0.03114505
Score: 0.973
Data Source: STRINGDB
MEPE
Tbio
Novelty: 0.00825085
Score: 0.972
Data Source: STRINGDB
AMBN
Tbio
Novelty: 0.00354946
Score: 0.971
Data Source: STRINGDB
AMTN
Tbio
Novelty: 0.02514528
Score: 0.969
Data Source: STRINGDB
AHSG
Tbio
Novelty: 0.00112502
Score: 0.946
Data Source: STRINGDB
Publication Statistics
PubMed Score  319.16

PubMed score by year
PubTator Score  67.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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