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Tbio
ATG4C
Cysteine protease ATG4C

Protein Summary
Description
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation (By similarity). Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for auto ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317868
  • ENSP00000322159
  • ENSG00000125703
  • ENST00000371120
  • ENSP00000360161

Symbol
  • APG4C
  • AUTL1
  • AUTL3
  • APG4C
  • AUTL1
  • AUTL3
  • APG4-C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
histone modification site profile
0.85
transcription factor
0.74
virus perturbation
0.68
tissue
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.8   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 502   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.8   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 502   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (5)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (115)
1 – 10 of 115
CLCN6
Tchem
Family: IC
Novelty: 0.02775193
p_int: 0.999999909
p_ni: 8.2e-8
p_wrong: 8e-9
Data Source: BioPlex
GABARAPL1
Tbio
Novelty: 0.00212657
p_int: 0.999999894
p_ni: 4.2e-8
p_wrong: 6.4e-8
Score: 0.979
Data Source: BioPlex,STRINGDB
ATG4D
Tbio
Family: Enzyme
Novelty: 0.07285957
p_int: 0.99999719
p_ni: 1.68e-7
p_wrong: 0.000002642
Data Source: BioPlex
KLHL22
Tbio
Novelty: 0.24456252
p_int: 0.999996264
p_ni: 0.000003386
p_wrong: 3.5e-7
Score: 0.193
Data Source: BioPlex,STRINGDB
PIP4K2B
Tchem
Family: Kinase
Novelty: 0.06261627
p_int: 0.999991758
p_ni: 0.000008242
p_wrong: 1e-9
Data Source: BioPlex
PIP4K2C
Tchem
Family: Kinase
Novelty: 0.11466436
p_int: 0.999986898
p_ni: 0.000013102
Data Source: BioPlex
RAB3IL1
Tbio
Novelty: 0.0167537
p_int: 0.999958558
p_ni: 0.000038167
p_wrong: 0.000003275
Score: 0.237
Data Source: BioPlex,STRINGDB
WASL
Tbio
Novelty: 0.0029314
p_int: 0.999950059
p_ni: 0.000041955
p_wrong: 0.000007986
Score: 0.199
Data Source: BioPlex,STRINGDB
PIP4K2A
Tbio
Family: Kinase
Novelty: 0.01130885
p_int: 0.999926999
p_ni: 0.000070788
p_wrong: 0.000002213
Data Source: BioPlex
TRAF7
Tbio
Family: Enzyme
Novelty: 0.02437761
p_int: 0.997038019
p_ni: 0.00296198
p_wrong: 1e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  22.80

PubMed score by year
PubTator Score  5.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer