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Tbio
SLC25A22
Mitochondrial glutamate carrier 1

Protein Summary
Description
Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+). This gene encodes a mitochondrial glutamate carrier. Mutations in this gene are associated with early infantile epileptic encephalopathy. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320230
  • ENSP00000322020
  • ENSG00000177542
  • ENST00000531214
  • ENSP00000437236
  • ENST00000628067
  • ENSP00000486058

Symbol
  • GC1
  • GC1
  • GC-1
  • EIEE3
  • NET44
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
cell type or tissue
0.75
small molecule perturbation
0.73
transcription factor
0.72
interacting protein
0.7


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.51   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.51   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
1
1
1
67.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
1
67.2
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 25 member 22
700463
Mouse
MGI:1915517
68267
Rat
RGD:1307826
309111
Horse
solute carrier family 25 member 22 [Source:HGNC Symbol;Acc:HGNC:19954]
Cow
solute carrier family 25 member 22
VGNC:34750
504371
Species
Name
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 25 member 22
Mouse
Rat
Horse
solute carrier family 25 member 22 [Source:HGNC Symbol;Acc:HGNC:19954]
Cow
solute carrier family 25 member 22
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H936-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Organic anion transporters (R-HSA-428643)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Organic anion transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Organic anion transporters
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Protein-Protein Interactions (46)
1 – 10 of 46
SLC25A18
Tbio
Family: Transporter
Novelty: 0.00270676
p_int: 0.999940849
p_ni: 0.000059151
Score: 0.696
Data Source: BioPlex,STRINGDB
WDTC1
Tbio
Novelty: 0.02300849
p_int: 0.98463847
p_ni: 0.01536153
Score: 0.558
Data Source: BioPlex,STRINGDB
DNLZ
Tdark
Novelty: 0.10113346
p_int: 0.982301948
p_ni: 0.017698044
p_wrong: 8e-9
Score: 0.279
Data Source: BioPlex,STRINGDB
GUCA1A
Tbio
Family: Enzyme
Novelty: 0.01003665
Score: 0.906
Data Source: STRINGDB
CDKL5
Tchem
Family: Kinase
Novelty: 0.00444062
Score: 0.681
Data Source: STRINGDB
PNKP
Tbio
Family: Enzyme
Novelty: 0.01038571
Score: 0.666
Data Source: STRINGDB
STXBP1
Tbio
Novelty: 0.00339098
Score: 0.663
Data Source: STRINGDB
PCDH19
Tbio
Novelty: 0.01282021
Score: 0.641
Data Source: STRINGDB
PCDH10
Tbio
Novelty: 0.01058382
Score: 0.641
Data Source: STRINGDB
KCNT1
Tchem
Family: IC
Novelty: 0.0103988
Score: 0.637
Data Source: STRINGDB
Publication Statistics
PubMed Score  19.51

PubMed score by year
PubTator Score  119.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer