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Tbio
TRIT1
tRNA dimethylallyltransferase

Protein Summary
Description
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). This gene encodes a protein that that is targeted to the mitochondrion and modifies transfer RNAs (tRNAs) by adding a dimethylallyl group onto the adenine at position 37. This modification is important for maintaining the correct reading frame during protein translation. This gene is considered a tumor suppressor and its expression can decrease cell growth. Alternative splicing results in multiple transcripts variants, most of which are likely non-functional. [provided by RefSeq, Aug 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316891
  • ENSP00000321810
  • ENSG00000043514
  • ENST00000372818
  • ENSP00000361905
  • ENST00000441669
  • ENSP00000388333
  • ENST00000537440
  • ENSP00000437700

Symbol
  • IPT
  • MOD5
  • IPT
  • GRO1
  • IPPT
  • MOD5
  • hGRO1
  • IPTase
  • COXPD35
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
molecular function
0.88
ligand (protein) perturbation
0.83
kinase perturbation
0.71
cell line
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 353.35   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 353.35   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
1
1
45.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
45.1
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tRNA isopentenyltransferase 1
VGNC:1705
456785
Macaque
tRNA isopentenyltransferase 1
716422
Mouse
MGI:1914216
66966
Rat
RGD:1304781
362586
Dog
tRNA isopentenyltransferase 1
VGNC:47848
475320
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tRNA isopentenyltransferase 1
Macaque
tRNA isopentenyltransferase 1
Mouse
Rat
Dog
tRNA isopentenyltransferase 1
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the mitochondrion
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the mitochondrion
tRNA modification in the nucleus and cytosol
tRNA processing
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (117)
1 – 10 of 117
ANKRD49
Tbio
Novelty: 0.00254346
Score: 0.913
Data Source: STRINGDB
TRMT1
Tbio
Family: Enzyme
Novelty: 0.01795504
Score: 0.851
Data Source: STRINGDB
TRMT5
Tbio
Family: Enzyme
Novelty: 0.02509765
Score: 0.819
Data Source: STRINGDB
TRMT10A
Tbio
Family: Enzyme
Novelty: 0.04694256
Score: 0.801
Data Source: STRINGDB
PUS1
Tbio
Family: Enzyme
Novelty: 0.01923618
Score: 0.796
Data Source: STRINGDB
MTFMT
Tbio
Family: Enzyme
Novelty: 0.011101
Score: 0.793
Data Source: STRINGDB
METTL1
Tbio
Family: Enzyme
Novelty: 0.03641249
Score: 0.779
Data Source: STRINGDB
TRMU
Tbio
Family: Enzyme
Novelty: 0.01615197
Score: 0.774
Data Source: STRINGDB
DUS2
Tbio
Family: Enzyme
Novelty: 0.05121878
Score: 0.768
Data Source: STRINGDB
TMCO2
Tdark
Novelty: 0.18671657
Score: 0.762
Data Source: STRINGDB
Publication Statistics
PubMed Score  353.35

PubMed score by year
PubTator Score  286.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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