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Tbio
TNIP2
TNFAIP3-interacting protein 2

Protein Summary
Description
Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes. This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in apoptosis of endothelial cells. Alternative splicing results in multiple transcrip ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315423
  • ENSP00000321203
  • ENSG00000168884
  • ENST00000510267
  • ENSP00000427613

Symbol
  • ABIN2
  • FLIP1
  • KLIP
  • ABIN2
  • FLIP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.92
drug perturbation
0.87
kinase perturbation
0.81
disease perturbation
0.74
transcription factor binding site profile
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.61   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.61   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aging
1
1
1
70.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
aging
1
70.3
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (56)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 29
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Deubiquitination
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Interleukin-1 family signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Deubiquitination
Immune System
Innate Immune System
Interleukin-1 family signaling
Protein-Protein Interactions (47)
1 – 10 of 47
RAB11FIP4
Tbio
Novelty: 0.13545871
p_int: 0.999999782
p_ni: 2.17e-7
p_wrong: 1e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
DKK3
Tbio
Novelty: 0.00519275
p_int: 0.999990347
p_ni: 0.000009652
p_wrong: 1e-9
Data Source: BioPlex
SSSCA1
Tdark
Novelty: 0.53523038
p_int: 0.999974215
p_ni: 0.000024837
p_wrong: 9.48e-7
Data Source: BioPlex
C16orf71
Tdark
Novelty: 0.97826087
p_int: 0.999966728
p_ni: 0.000033271
p_wrong: 1e-9
Data Source: BioPlex
RELB
Tbio
Family: TF
Novelty: 0.00216805
p_int: 0.999944693
p_ni: 0.000055306
p_wrong: 2e-9
Score: 0.737
Data Source: BioPlex,STRINGDB
CCDC40
Tbio
Novelty: 0.06726469
p_int: 0.999934922
p_ni: 0.000065076
p_wrong: 2e-9
Score: 0.173
Data Source: BioPlex,STRINGDB
REL
Tbio
Family: TF
Novelty: 0.00038265
p_int: 0.99974125
p_ni: 0.000242185
p_wrong: 0.000016565
Score: 0.681
Data Source: BioPlex,STRINGDB
EMILIN1
Tbio
Novelty: 0.02550566
p_int: 0.98686654
p_ni: 0.013099556
p_wrong: 0.000033904
Score: 0.162
Data Source: BioPlex,STRINGDB
MAP3K8
Tchem
Family: Kinase
Novelty: 0.00581582
Score: 0.988
Data Source: Reactome,STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.981
Data Source: STRINGDB
Publication Statistics
PubMed Score  28.61

PubMed score by year
PubTator Score  27.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer