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Tbio
DEFB103A
Beta-defensin 103

Protein Summary
Description
Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed. Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 103, an antibiotic peptide which is induced by bacteria and interferon gamma, and which displays antimicrobial activity against S. aureus, S. pyogenes, P. aeruginosa, E. coli, and C. albicans. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314357
  • ENSP00000320951
  • ENSG00000176797
  • ENST00000318124
  • ENSP00000324633
  • ENSG00000177243
  • ENST00000613448
  • ENSP00000480773
  • ENSG00000273641
  • ENST00000642635
  • ENSP00000495040
  • ENSG00000285376
  • ENST00000646258
  • ENSP00000493640
  • ENST00000646344
  • ENSP00000493616
  • ENSG00000284978

Symbol
  • BD3
  • DEFB103
  • DEFB3
  • BD-3
  • HBD3
  • HBP3
  • DEFB3
  • HBP-3
  • DEFB-3
  • DEFB103
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.85
disease
0.57
cell line
0.54
tissue
0.47
phenotype
0.41


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 316.16   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 316.16   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
defensin, beta 103A
450106
Macaque
beta-defensin 103
694235
Mouse
MGI:2675345
244332
Rat
RGD:1561378
641627
Dog
beta-defensin 103
100170103
Species
Name
OMA
EggNOG
Inparanoid
Chimp
defensin, beta 103A
Macaque
beta-defensin 103
Mouse
Rat
Dog
beta-defensin 103
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P81534-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Beta defensins
Reactome
Defensins
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Beta defensins
Defensins
Immune System
Innate Immune System
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (64)
1 – 10 of 64
DEFB1
Tbio
Novelty: 0.00144458
Score: 0.952
Data Source: STRINGDB
CAMP
Tbio
Novelty: 0.00064433
Score: 0.839
Data Source: STRINGDB
HBD
Tbio
Novelty: 0.00203187
Score: 0.808
Data Source: STRINGDB
RNASE7
Tbio
Family: Enzyme
Novelty: 0.01866347
Score: 0.798
Data Source: STRINGDB
DEFB105A
Tbio
Novelty: 0.03235589
Score: 0.773
Data Source: STRINGDB
DEFB104A
Tbio
Novelty: 0.0468791
Score: 0.772
Data Source: STRINGDB
DEFB106A
Tbio
Novelty: 0.0474196
Score: 0.756
Data Source: STRINGDB
TLR2
Tchem
Novelty: 0.00023242
Score: 0.736
Data Source: Reactome,STRINGDB
HBB
Tbio
Novelty: 0.00049683
Score: 0.731
Data Source: STRINGDB
DEFB107A
Tdark
Novelty: 0.20848172
Score: 0.731
Data Source: STRINGDB
Publication Statistics
PubMed Score  316.16

PubMed score by year
PubTator Score  14.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer