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Tbio
KIF1C
Kinesin-like protein KIF1C

Protein Summary
Description
Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility. The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. Mutations in this gene are a cause of spastic ataxia 2, autosomal recessive. [provided by RefSeq, May 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320785
  • ENSP00000320821
  • ENSG00000129250

Symbol
  • KIAA0706
  • SAX2
  • LTXS1
  • SATX2
  • SPAX2
  • SPG58
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
virus perturbation
0.94
kinase perturbation
0.93
protein domain
0.85
disease perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.13   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 126   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.13   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
49.4
reticulocyte count
1
1
1
17.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
49.4
reticulocyte count
1
17.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 1C
VGNC:9347
454459
Macaque
kinesin family member 1C
721601
Mouse
MGI:1098260
16562
Rat
RGD:70928
113886
Dog
kinesin family member 1C
VGNC:42393
489453
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 1C
Macaque
kinesin family member 1C
Mouse
Rat
Dog
kinesin family member 1C
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43896-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
COPI-dependent Golgi-to-ER retrograde traffic (R-HSA-6811434)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Golgi-to-ER retrograde transport
Reactome
Hemostasis
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Name
Explore in Pharos
Explore in Source
COPI-dependent Golgi-to-ER retrograde traffic
Factors involved in megakaryocyte development and platelet production
Golgi-to-ER retrograde transport
Hemostasis
Intra-Golgi and retrograde Golgi-to-ER traffic
Gene Ontology Terms (21)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (137)
1 – 10 of 137
KIF1BP
Tbio
Novelty: 0.03932922
p_int: 0.99980141
p_ni: 0.00019854
p_wrong: 5e-8
Score: 0.597
Data Source: BioPlex,STRINGDB
CCDC9
Tdark
Novelty: 0.73149492
p_int: 0.99708189
p_ni: 0.002918103
p_wrong: 7e-9
Data Source: BioPlex
LARP4B
Tbio
Novelty: 0.11363794
p_int: 0.884646484
p_ni: 0.115213555
p_wrong: 0.00013996
Data Source: BioPlex
CALML3
Tbio
Novelty: 0.0336689
p_int: 0.875624704
p_ni: 0.124375238
p_wrong: 5.8e-8
Data Source: BioPlex
PRDM5
Tbio
Family: TF; Epigenetic
Novelty: 0.01689997
p_int: 0.874637188
p_ni: 0.052467885
p_wrong: 0.072894927
Score: 0.209
Data Source: BioPlex,STRINGDB
KIFAP3
Tbio
Novelty: 0.01902437
Score: 0.946
Data Source: STRINGDB
KLC2
Tbio
Novelty: 0.06284367
Score: 0.941
Data Source: STRINGDB
KLC4
Tdark
Novelty: 0.32552746
Score: 0.94
Data Source: STRINGDB
RINT1
Tbio
Novelty: 0.04546291
Score: 0.936
Data Source: STRINGDB
KLC3
Tbio
Novelty: 0.0528937
Score: 0.934
Data Source: STRINGDB
Publication Statistics
PubMed Score  31.13

PubMed score by year
PubTator Score  12.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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