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Tbio
TSPAN16
Tetraspanin-16

Protein Summary
Description
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein might couple to signal transduction pathways and possibly modulate cellular activation and adhesion in haemopoietic and neural tissue. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316737
  • ENSP00000319486
  • ENSG00000130167
  • ENST00000337994
  • ENSP00000338759
  • ENST00000590327
  • ENSP00000467341
  • ENST00000592955
  • ENSP00000466751
  • ENST00000621731
  • ENSP00000480759

Symbol
  • TM4SF16
  • TM-8
  • TM4-B
  • TM4SF16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
1
cell type or tissue
0.63
kinase perturbation
0.54
cell line
0.48
tissue sample
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.11   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.11   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
39.1
high density lipoprotein cholesterol measurement
1
1
1
30.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
39.1
high density lipoprotein cholesterol measurement
1
30.3
Protein-Protein Interactions (42)
1 – 10 of 42
NPC2
Tbio
Novelty: 0.00342898
Score: 0.749
Data Source: STRINGDB
TRPC4
Tchem
Family: IC
Novelty: 0.00339889
Score: 0.71
Data Source: STRINGDB
COPRS
Tbio
Novelty: 0.03545787
Score: 0.655
Data Source: STRINGDB
SERINC1
Tbio
Novelty: 0.03556234
Score: 0.652
Data Source: STRINGDB
NPC1L1
Tclin
Novelty: 0.0033429
Score: 0.648
Data Source: STRINGDB
TRPC5
Tchem
Family: IC
Novelty: 0.00406517
Score: 0.647
Data Source: STRINGDB
FBLN7
Tbio
Novelty: 0.03423924
Score: 0.646
Data Source: STRINGDB
TSPAN32
Tbio
Novelty: 0.08323845
Score: 0.645
Data Source: STRINGDB
NPC1
Tbio
Novelty: 0.00155015
Score: 0.641
Data Source: STRINGDB
CD81
Tchem
Novelty: 0.00111328
Score: 0.631
Data Source: STRINGDB
Publication Statistics
PubMed Score  193.11

PubMed score by year
PubTator Score  51.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer