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Tbio
GIPC3
PDZ domain-containing protein GIPC3

Protein Summary
Description
Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion. The protein encoded by this gene belongs to the GIPC family. Studies in mice suggest that this gene is required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion in the ear. Mutations in this gene are associated with autosomal recessive deafness. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322315
  • ENSP00000319254
  • ENSG00000179855
  • ENST00000644452
  • ENSP00000493901

Symbol
  • C19orf64
  • DFNB15
  • DFNB72
  • DFNB95
  • C19orf64
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.68
tissue sample
0.66
microRNA
0.62
gene perturbation
0.53
tissue
0.49


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.18   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.18   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GIPC PDZ domain containing family member 3
VGNC:11122
735695
Macaque
GIPC PDZ domain containing family member 3
713364
Mouse
MGI:2387006
209047
Rat
RGD:1563255
500789
Dog
GIPC PDZ domain containing family member 3
VGNC:41227
485057
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GIPC PDZ domain containing family member 3
Macaque
GIPC PDZ domain containing family member 3
Mouse
Rat
Dog
GIPC PDZ domain containing family member 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8TF64-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (61)
1 – 10 of 61
MYO6
Tbio
Novelty: 0.01073438
Score: 0.866
Data Source: STRINGDB
PJVK
Tbio
Novelty: 0.0419213
Score: 0.788
Data Source: STRINGDB
ZNRF4
Tbio
Novelty: 0.16505328
Score: 0.754
Data Source: STRINGDB
BSND
Tbio
Novelty: 0.01638636
Score: 0.728
Data Source: STRINGDB
MYO1F
Tbio
Novelty: 0.06367196
Score: 0.724
Data Source: STRINGDB
GRXCR1
Tdark
Novelty: 0.17455124
Score: 0.682
Data Source: STRINGDB
FZD3
Tbio
Family: GPCR
Novelty: 0.00964507
Score: 0.669
Data Source: STRINGDB
MYO3A
Tbio
Family: Kinase
Novelty: 0.0364819
Score: 0.664
Data Source: STRINGDB
MYO1H
Tdark
Novelty: 0.13056549
Score: 0.633
Data Source: STRINGDB
ANKRD24
Tdark
Novelty: 1.1511349
Score: 0.618
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.18

PubMed score by year
PubTator Score  10.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer