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Tclin
TPO
Thyroid peroxidase

Protein Summary
Description
Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4). This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329066
  • ENSP00000329869
  • ENSG00000115705
  • ENST00000345913
  • ENSP00000318820
  • ENST00000346956
  • ENSP00000263886
  • ENST00000382198
  • ENSP00000371633
  • ENST00000382201
  • ENSP00000371636

Symbol
  • MSA
  • TPX
  • TDH2A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
biological term
0.83
gene perturbation
0.81
cellular component
0.67
cell type or tissue
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 873.5   (req: < 5)
Gene RIFs: 112   (req: <= 3)
Antibodies: 520   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 873.5   (req: >= 5)
Gene RIFs: 112   (req: > 3)
Antibodies: 520   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thyroid peroxidase antibody measurement
3
2
1
1.4
91.5
autoimmune thyroid disease
1
1
0
1.1
71
2
1
1
1.1
70.2
Thyroid preparation use measurement
1
1
1
54.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thyroid peroxidase antibody measurement
1
1.4
91.5
autoimmune thyroid disease
0
1.1
71
1
1.1
70.2
Thyroid preparation use measurement
1
54.5
Pathways (21)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amine-derived hormones
Reactome
Metabolism of amino acids and derivatives
Reactome
Thyroxine biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amine-derived hormones
Metabolism of amino acids and derivatives
Thyroxine biosynthesis
Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (73)
1 – 10 of 73
TG
Tbio
Novelty: 0.00010111
Score: 0.942
Data Source: STRINGDB
TH
Tclin
Family: Enzyme
Novelty: 0.00025719
Score: 0.917
Data Source: STRINGDB
TYR
Tclin
Family: Enzyme
Novelty: 0.00048513
Score: 0.914
Data Source: STRINGDB
DDC
Tclin
Family: Enzyme
Novelty: 0.0012284
Score: 0.911
Data Source: STRINGDB
IL4I1
Tbio
Family: Enzyme
Novelty: 0.00414355
Score: 0.907
Data Source: STRINGDB
CTSD
Tchem
Family: Enzyme
Novelty: 0.00029823
Score: 0.905
Data Source: STRINGDB
GOT1
Tbio
Family: Enzyme
Novelty: 0.00448817
Score: 0.902
Data Source: STRINGDB
GOT2
Tbio
Family: Enzyme
Novelty: 0.00054023
Score: 0.902
Data Source: STRINGDB
TAT
Tbio
Family: Enzyme
Novelty: 0.00079176
Score: 0.902
Data Source: STRINGDB
TSHR
Tclin
Family: GPCR
Novelty: 0.00074972
Score: 0.883
Data Source: STRINGDB
Publication Statistics
PubMed Score  873.50

PubMed score by year
PubTator Score  1548.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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