You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
TUBB6
Tubulin beta-6 chain

Protein Summary
Description
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317702
  • ENSP00000318697
  • ENSG00000176014

Symbol
  • FPVEPD
  • TUBB-5
  • HsT1601
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein complex
1
protein domain
0.97
disease perturbation
0.96
virus perturbation
0.96


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.23   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.23   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tubulin beta 6 class V
VGNC:10010
455508
Mouse
MGI:1915201
67951
Rat
RGD:1305887
307351
Dog
tubulin beta 6 class V
VGNC:47991
480213
Horse
tubulin beta 6 class V
VGNC:50983
100058421
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tubulin beta 6 class V
Mouse
Rat
Dog
tubulin beta 6 class V
Horse
tubulin beta 6 class V
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BUF5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (21)
Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Reactome
Formation of tubulin folding intermediates by CCT/TriC
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Carboxyterminal post-translational modifications of tubulin
Chaperonin-mediated protein folding
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Formation of tubulin folding intermediates by CCT/TriC
Metabolism of proteins
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (96)
1 – 10 of 96
CAPS
Tbio
Novelty: 0.04549022
p_int: 0.857094762
p_ni: 0.142905238
Data Source: BioPlex
OSTM1
Tbio
Novelty: 0.03033192
p_int: 0.790155172
p_ni: 0.209844828
Data Source: BioPlex
TUBA1C
Tchem
Novelty: 0.02804632
Score: 0.987
Data Source: STRINGDB
TUBA1B
Tchem
Novelty: 0.02465964
Score: 0.986
Data Source: STRINGDB
TUBA1A
Tchem
Novelty: 0.01030145
Score: 0.982
Data Source: STRINGDB
TBCA
Tbio
Novelty: 0.07587729
Score: 0.953
Data Source: STRINGDB
TBCD
Tbio
Novelty: 0.01161221
Score: 0.95
Data Source: STRINGDB
TUBA4A
Tchem
Novelty: 0.00820546
Score: 0.949
Data Source: STRINGDB
TBCE
Tbio
Novelty: 0.01058281
Score: 0.943
Data Source: STRINGDB
TUBA8
Tbio
Novelty: 0.06454549
Score: 0.938
Data Source: STRINGDB
Publication Statistics
PubMed Score  20.23

PubMed score by year
PubTator Score  7.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer