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Tbio
YME1L1
ATP-dependent zinc metalloprotease YME1L1

Protein Summary
Description
ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (PubMed:26923599, PubMed:27786171). Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism (PubMed:18076378, PubMed:26923599, PubMed:27495975). Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins (PubMed:22262461). Required for normal, constitutive degradation of PRELID1 (PubMed:27495975). Catalyzes the degradation of OMA1 in response to membrane depolarization (PubMed:26923599). Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326799
  • ENSP00000318480
  • ENSG00000136758
  • ENST00000376016
  • ENSP00000365184
  • ENST00000613434
  • ENSP00000481724

Symbol
  • FTSH1
  • YME1L
  • FTSH
  • MEG4
  • PAMP
  • OPA11
  • YME1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
molecular function
0.93
disease perturbation
0.9
transcription factor perturbation
0.88
protein domain
0.85


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 573.31   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 573.31   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
YME1 like 1 ATPase
VGNC:5883
450366
Macaque
YME1 like 1 ATPase
714687
Mouse
MGI:1351651
27377
Rat
RGD:620764
114217
Dog
YME1 like 1 ATPase
VGNC:48495
477988
Species
Name
OMA
EggNOG
Inparanoid
Chimp
YME1 like 1 ATPase
Macaque
YME1 like 1 ATPase
Mouse
Rat
Dog
YME1 like 1 ATPase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96TA2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Mitochondrial calcium ion transport (R-HSA-8949215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial calcium ion transport
Reactome
Processing of SMDT1
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Mitochondrial calcium ion transport
Processing of SMDT1
Transport of small molecules
Protein-Protein Interactions (166)
1 – 10 of 166
TTC25
Tdark
Novelty: 0.23064129
p_int: 0.993013639
p_ni: 0.006986361
Score: 0.639
Data Source: BioPlex,STRINGDB
PARL
Tbio
Family: Enzyme
Novelty: 0.01317944
Score: 0.976
Data Source: Reactome,STRINGDB
STOML2
Tbio
Novelty: 0.07828354
Score: 0.926
Data Source: Reactome,STRINGDB
OMA1
Tbio
Family: Enzyme
Novelty: 0.00963387
Score: 0.912
Data Source: STRINGDB
SMDT1
Tbio
Novelty: 0.02448475
Score: 0.904
Data Source: STRINGDB
ATP5F1A
Tbio
Family: Enzyme
Novelty: 0.01052213
Score: 0.9
Data Source: STRINGDB
CLPX
Tbio
Family: Enzyme
Novelty: 0.00254331
Score: 0.876
Data Source: STRINGDB
CLPP
Tbio
Family: Enzyme
Novelty: 0.00105289
Score: 0.874
Data Source: STRINGDB
LONP1
Tbio
Family: Enzyme
Novelty: 0.00334137
Score: 0.849
Data Source: STRINGDB
HSPD1
Tbio
Novelty: 0.00018924
Score: 0.818
Data Source: STRINGDB
Publication Statistics
PubMed Score  573.31

PubMed score by year
PubTator Score  95.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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