You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SH2D3C
SH2 domain-containing protein 3C

Protein Summary
Description
Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration (By similarity). This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314830
  • ENSP00000317817
  • ENSG00000095370
  • ENST00000373276
  • ENSP00000362373
  • ENST00000373277
  • ENSP00000362374
  • ENST00000420366
  • ENSP00000388536
  • ENST00000429553
  • ENSP00000394632
  • ENST00000629203
  • ENSP00000485866

Symbol
  • NSP3
  • CHAT
  • NSP3
  • SHEP1
  • PRO34088
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
tissue sample
0.73
transcription factor
0.69
PubMedID
0.63
cell line
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 291.27   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 257   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 291.27   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
2
2
47.2
neutrophil percentage of leukocytes
1
1
1
26.3
granulocyte percentage of myeloid white cells
1
1
1
23.9
basophil percentage of leukocytes
1
1
1
20.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
47.2
neutrophil percentage of leukocytes
1
26.3
granulocyte percentage of myeloid white cells
1
23.9
basophil percentage of leukocytes
1
20.9
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (57)
1 – 10 of 57
BCAR1
Tbio
Novelty: 0.00329214
Score: 0.977
Data Source: STRINGDB
PRSS57
Tbio
Family: Enzyme
Novelty: 0.00250647
Score: 0.954
Data Source: STRINGDB
SPECC1
Tbio
Novelty: 0.00830299
Score: 0.921
Data Source: STRINGDB
NEDD9
Tbio
Novelty: 0.00539079
Score: 0.888
Data Source: STRINGDB
MRPL58
Tbio
Family: Enzyme
Novelty: 0.00178011
Score: 0.797
Data Source: STRINGDB
BAG6
Tbio
Novelty: 0.0035578
Score: 0.795
Data Source: STRINGDB
G3BP1
Tbio
Family: Enzyme
Novelty: 0.00589987
Score: 0.738
Data Source: STRINGDB
EIF4G1
Tbio
Novelty: 0.00170995
Score: 0.73
Data Source: STRINGDB
C6orf48
Tdark
Novelty: 0.00615017
Score: 0.709
Data Source: STRINGDB
EML3
Tdark
Novelty: 0.26210133
Score: 0.688
Data Source: STRINGDB
Publication Statistics
PubMed Score  291.27

PubMed score by year
PubTator Score  174.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: