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Tbio
UBASH3A
Ubiquitin-associated and SH3 domain-containing protein A

Protein Summary
Description
Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain. This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291535
  • ENSP00000291535
  • ENSG00000160185
  • ENST00000319294
  • ENSP00000317327
  • ENST00000398367
  • ENSP00000381408

Symbol
  • STS2
  • TULA
  • CLIP4
  • STS-2
  • TULA-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.93
protein domain
0.85
tissue sample
0.73
phenotype
0.65
disease
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.75   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.75   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.3
93.4
2
2
0
1.2
89.1
eosinophil count
2
1
2
67.3
1
1
0
1.2
66.7
3
1
2
1.1
63.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
93.4
0
1.2
89.1
eosinophil count
2
67.3
0
1.2
66.7
2
1.1
63.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin associated and SH3 domain containing A
VGNC:1116
474125
Mouse
MGI:1926074
328795
Rat
RGD:1310305
309666
Horse
ubiquitin associated and SH3 domain containing A
VGNC:24710
100057923
Cow
ubiquitin associated and SH3 domain containing A
VGNC:36574
514555
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin associated and SH3 domain containing A
Mouse
Rat
Horse
ubiquitin associated and SH3 domain containing A
Cow
ubiquitin associated and SH3 domain containing A
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P57075-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (51)
1 – 10 of 51
LCP2
Tbio
Novelty: 0.00512968
Score: 0.901
Data Source: STRINGDB
ZAP70
Tchem
Family: Kinase
Novelty: 0.0011564
Score: 0.875
Data Source: STRINGDB
ARSI
Tbio
Family: Enzyme
Novelty: 0.04002595
Score: 0.676
Data Source: STRINGDB
PTPN22
Tchem
Family: Enzyme
Novelty: 0.00168847
Score: 0.671
Data Source: STRINGDB
CBL
Tbio
Family: Enzyme
Novelty: 0.00114929
Score: 0.656
Data Source: STRINGDB
SYK
Tclin
Family: Kinase
Novelty: 0.00058994
Score: 0.634
Data Source: STRINGDB
LAT
Tbio
Novelty: 0.00738419
Score: 0.623
Data Source: STRINGDB
EGFR
Tclin
Family: Kinase
Novelty: 0.00007274
Score: 0.617
Data Source: STRINGDB
PGAM4
Tbio
Family: Enzyme
Novelty: 0.03784125
Score: 0.616
Data Source: STRINGDB
RNF41
Tbio
Family: Enzyme
Novelty: 0.01953473
Score: 0.611
Data Source: STRINGDB
Publication Statistics
PubMed Score  75.75

PubMed score by year
PubTator Score  63.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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