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Tbio
CYC1
Cytochrome c1, heme protein, mitochondrial

Protein Summary
Description
This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain. This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear type 6. [provided by RefSeq, Dec 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318911
  • ENSP00000317159
  • ENSG00000179091

Symbol
  • UQCR4
  • MC3DN6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
co-expressed gene
0.99
kinase perturbation
0.91
virus perturbation
0.83
transcription factor perturbation
0.8


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.56   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 371   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.56   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 371   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome c1
VGNC:6683
472893
Macaque
cytochrome c-1
700518
Mouse
MGI:1913695
66445
Dog
cytochrome c1
VGNC:50287
475121
Horse
cytochrome c1
VGNC:49118
100146668
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome c1
Macaque
cytochrome c-1
Mouse
Dog
cytochrome c1
Horse
cytochrome c1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P08574-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (24)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Mitochondrial protein import
Reactome
Protein localization
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Name
Explore in Pharos
Explore in Source
Metabolism
Mitochondrial protein import
Protein localization
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (305)
1 – 10 of 305
HCCS
Tbio
Family: Enzyme
Novelty: 0.0022585
p_int: 0.999895592
p_ni: 0.000104408
Score: 0.813
Data Source: BioPlex,STRINGDB
UQCRH
Tbio
Novelty: 0.04494433
p_int: 0.987828044
p_ni: 0.012171956
Score: 0.999
Data Source: BioPlex,STRINGDB
PTGES2
Tchem
Family: Enzyme
Novelty: 0.01415352
p_int: 0.96599556
p_ni: 0.03400444
Score: 0.378
Data Source: BioPlex,STRINGDB
PEX19
Tbio
Novelty: 0.00605342
p_int: 0.956886723
p_ni: 0.043113277
Score: 0.277
Data Source: BioPlex,STRINGDB
UQCRB
Tbio
Novelty: 0.02933046
p_int: 0.936677682
p_ni: 0.063322318
Score: 0.999
Data Source: BioPlex,STRINGDB
SCYL3
Tbio
Family: Kinase
Novelty: 0.13735583
p_int: 0.930026635
p_ni: 0.069973365
Data Source: BioPlex
MT-CYB
Tbio
Novelty: 0.00012093
Score: 0.999
Data Source: STRINGDB
UQCRC2
Tbio
Family: Enzyme
Novelty: 0.01584406
Score: 0.999
Data Source: STRINGDB
UQCRQ
Tbio
Novelty: 0.04392627
Score: 0.999
Data Source: STRINGDB
UQCR10
Tbio
Novelty: 0.04536078
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  58.56

PubMed score by year
PubTator Score  54.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer