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Tbio
GPM6B
Neuronal membrane glycoprotein M6-b

Protein Summary
Description
May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake. This gene encodes a membrane glycoprotein that belongs to the proteolipid protein family. Proteolipid protein family members are expressed in most brain regions and are thought to be involved in cellular housekeeping functions such as membrane trafficking and cell-to-cell communication. This protein may also be involved in osteoblast differentiation. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are located on chromosomes Y and 22. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316715
  • ENSP00000316861
  • ENSG00000046653
  • ENST00000355135
  • ENSP00000347258
  • ENST00000356942
  • ENSP00000349420
  • ENST00000454189
  • ENSP00000389915

Symbol
  • M6B
  • M6B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.96
transcription factor perturbation
0.96
small molecule perturbation
0.82
kinase perturbation
0.81
microRNA
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.47   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.47   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
delayed reward discounting measurement
1
1
1
62.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
delayed reward discounting measurement
1
62.5
Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (50)
1 – 10 of 50
NUFIP1
Tbio
Novelty: 0.11726869
p_int: 0.999935938
p_ni: 0.000006718
p_wrong: 0.000057344
Data Source: BioPlex
ADGRG5
Tdark
Family: GPCR
Novelty: 0.26575982
p_int: 0.997385381
p_ni: 0.000003857
p_wrong: 0.002610761
Data Source: BioPlex
HAX1
Tbio
Novelty: 0.00749205
p_int: 0.997150995
p_ni: 0.002849005
Score: 0.177
Data Source: BioPlex,STRINGDB
NME2P1
Tdark
Family: Kinase
p_int: 0.945997598
p_ni: 0.0540024
p_wrong: 2e-9
Data Source: BioPlex
ZDHHC15
Tbio
Family: Enzyme
Novelty: 0.14743456
Score: 0.686
Data Source: STRINGDB
NLGN4X
Tbio
Family: Enzyme
Novelty: 0.01004489
Score: 0.668
Data Source: STRINGDB
ASB12
Tdark
Novelty: 0.53300121
Score: 0.657
Data Source: STRINGDB
NTNG1
Tbio
Novelty: 0.04742965
Score: 0.653
Data Source: STRINGDB
NTNG2
Tbio
Novelty: 0.02827688
Score: 0.641
Data Source: STRINGDB
B3GNT5
Tbio
Family: Enzyme
Novelty: 0.08038327
Score: 0.636
Data Source: STRINGDB
Publication Statistics
PubMed Score  77.47

PubMed score by year
PubTator Score  27.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer