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Tbio
SIX5
Homeobox protein SIX5

Protein Summary
Description
Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 (By similarity). The protein encoded by this gene is a homeodomain-containing transcription factor that appears to function in the regulation of organogenesis. This gene is located downstream of the dystrophia myotonica-protein kinase gene. Mutations in this gene are a cause of branchiootorenal syndrome type 2. [provided by RefSeq, Jul 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317578
  • ENSP00000316842
  • ENSG00000177045
  • ENST00000643139
  • ENSP00000494267

Symbol
  • DMAHP
  • BOR2
  • DMAHP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.81
transcription factor
0.75
histone modification site profile
0.73
transcription factor binding site profile
0.73
tissue sample
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.62   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.62   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (12)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (54)
1 – 10 of 54
EYA1
Tbio
Novelty: 0.00585286
Score: 0.856
Data Source: STRINGDB
DMPK
Tchem
Family: Kinase
Novelty: 0.00242339
Score: 0.714
Data Source: STRINGDB
EYA3
Tbio
Novelty: 0.05588286
Score: 0.677
Data Source: STRINGDB
EYA4
Tbio
Novelty: 0.01905381
Score: 0.666
Data Source: STRINGDB
EYA2
Tbio
Novelty: 0.01972903
Score: 0.637
Data Source: STRINGDB
DMWD
Tbio
Novelty: 0.04096001
Score: 0.619
Data Source: STRINGDB
INHBB
Tbio
Novelty: 0.0154773
Score: 0.598
Data Source: STRINGDB
DACH1
Tbio
Novelty: 0.00986576
Score: 0.597
Data Source: STRINGDB
INHA
Tbio
Novelty: 0.00168407
Score: 0.581
Data Source: STRINGDB
IGFBP5
Tchem
Novelty: 0.0025185
Score: 0.556
Data Source: STRINGDB
Publication Statistics
PubMed Score  59.62

PubMed score by year
PubTator Score  100.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer