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Tbio
BIN1
Myc box-dependent-interacting protein 1

Protein Summary
Description
Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:24755653). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (PubMed:8782822). Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed:28893863). This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor sup ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259238
  • ENSP00000259238
  • ENSG00000136717
  • ENST00000316724
  • ENSP00000316779
  • ENST00000346226
  • ENSP00000315411
  • ENST00000348750
  • ENSP00000259237
  • ENST00000351659
  • ENSP00000315388
  • ENST00000352848
  • ENSP00000315284
  • ENST00000357970
  • ENSP00000350654
  • ENST00000376113
  • ENSP00000365281
  • ENST00000393040
  • ENSP00000376760
  • ENST00000393041
  • ENSP00000376761
  • ENST00000409400
  • ENSP00000386797

Symbol
  • AMPHL
  • CNM2
  • AMPH2
  • AMPHL
  • SH3P9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor perturbation
0.98
disease perturbation
0.96
PubMedID
0.92
interacting protein
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 324.69   (req: < 5)
Gene RIFs: 103   (req: <= 3)
Antibodies: 390   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 324.69   (req: >= 5)
Gene RIFs: 103   (req: > 3)
Antibodies: 390   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
14
6
0
1.2
99.8
family history of Alzheimer’s disease
5
2
0
1.1
98.1
neutrophil count
2
2
2
59.7
C-reactive protein measurement
1
1
1
57.6
late-onset Alzheimers disease
1
1
0
1.1
33.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
99.8
family history of Alzheimer’s disease
0
1.1
98.1
neutrophil count
2
59.7
C-reactive protein measurement
1
57.6
late-onset Alzheimers disease
0
1.1
33.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
bridging integrator 1
713587
Mouse
MGI:108092
30948
Rat
RGD:621786
117028
Dog
bridging integrator 1
VGNC:38458
483870
Horse
bridging integrator 1
VGNC:15830
100052213
Species
Name
OMA
EggNOG
Inparanoid
Macaque
bridging integrator 1
Mouse
Rat
Dog
bridging integrator 1
Horse
bridging integrator 1
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O00499-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (27)
Clathrin-mediated endocytosis (R-HSA-8856828)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Clathrin-mediated endocytosis
Membrane Trafficking
Vesicle-mediated transport
Gene Ontology Terms (45)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
WormBase
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
AgBase
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ARUK-UCL
Protein-Protein Interactions (291)
1 – 10 of 291
BIN2
Tbio
Novelty: 0.00952157
p_int: 1
Score: 0.988
Data Source: BioPlex,STRINGDB
AMPH
Tbio
Novelty: 0.00201043
p_int: 0.999999998
p_ni: 2e-9
Score: 0.97
Data Source: BioPlex,Reactome,STRINGDB
POLR2M
Tbio
Family: Enzyme
Novelty: 0.11413088
p_int: 0.999970042
p_ni: 0.000029957
p_wrong: 1e-9
Data Source: BioPlex
NCAPD3
Tbio
Novelty: 0.02819003
p_int: 0.999511676
p_ni: 0.000488321
p_wrong: 3e-9
Score: 0.188
Data Source: BioPlex,STRINGDB
DGUOK
Tbio
Family: Kinase
Novelty: 0.00897987
p_int: 0.837835165
p_ni: 0.027917655
p_wrong: 0.13424718
Score: 0.193
Data Source: BioPlex,STRINGDB
NUFIP1
Tbio
Novelty: 0.11726869
p_int: 0.837835165
p_ni: 0.027917655
p_wrong: 0.13424718
Data Source: BioPlex
MYC
Tbio
Family: TF
Novelty: 0.00005734
Score: 0.991
Data Source: STRINGDB
PICALM
Tbio
Novelty: 0.00800832
Score: 0.99
Data Source: STRINGDB
DNM2
Tchem
Novelty: 0.00265965
Score: 0.982
Data Source: STRINGDB
WASL
Tbio
Novelty: 0.0029314
Score: 0.979
Data Source: STRINGDB
Publication Statistics
PubMed Score  324.69

PubMed score by year
PubTator Score  164.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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