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Tbio
PACS1
Phosphofurin acidic cluster sorting protein 1

Protein Summary
Description
Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. [provided by RefSeq, Jul ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
transcription factor binding site profile
0.84
cellular component
0.73
small molecule perturbation
0.73
cell type or tissue
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.34   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.34   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
91.8
lifestyle measurement
1
1
1
80.1
1
1
0
1.2
47.9
bipolar I disorder
1
1
0
1.1
21.9
reticulocyte measurement
1
1
1
15.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
91.8
lifestyle measurement
1
80.1
0
1.2
47.9
bipolar I disorder
0
1.1
21.9
reticulocyte measurement
1
15.1
Pathways (7)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
HIV Infection
Reactome
Host Interactions of HIV factors
Reactome
Infectious disease
Reactome
Nef mediated downregulation of MHC class I complex cell surface expression
Name
Explore in Pharos
Explore in Source
Disease
HIV Infection
Host Interactions of HIV factors
Infectious disease
Nef mediated downregulation of MHC class I complex cell surface expression
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (63)
1 – 10 of 63
WDR37
Tbio
Novelty: 0.1677975
p_int: 0.999999966
p_ni: 2.1e-8
p_wrong: 1.2e-8
Score: 0.888
Data Source: BioPlex,STRINGDB
LEAP2
Tbio
Novelty: 0.01484908
p_int: 0.99999833
p_ni: 0.000001668
p_wrong: 2e-9
Data Source: BioPlex
IQCF1
Tdark
Novelty: 0.78525464
p_int: 0.999995609
p_ni: 0.000001821
p_wrong: 0.00000257
Score: 0.795
Data Source: BioPlex,STRINGDB
SNX24
Tdark
Novelty: 0.20838126
p_int: 0.999921071
p_ni: 0.000062163
p_wrong: 0.000016766
Score: 0.266
Data Source: BioPlex,STRINGDB
FGFR1OP
Tbio
Novelty: 0.09922864
Score: 0.89
Data Source: STRINGDB
CSNK2A1
Tchem
Family: Kinase
Novelty: 0.00187855
Score: 0.858
Data Source: STRINGDB
FURIN
Tchem
Family: Enzyme
Novelty: 0.00055079
Score: 0.831
Data Source: STRINGDB
BCAP31
Tbio
Novelty: 0.01363316
Score: 0.779
Data Source: STRINGDB
PKD2
Tchem
Family: IC
Novelty: 0.00305329
Score: 0.771
Data Source: STRINGDB
S100B
Tchem
Novelty: 0.00031007
Score: 0.72
Data Source: STRINGDB
Publication Statistics
PubMed Score  49.34

PubMed score by year
PubTator Score  31.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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