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Tclin
HTR1A
5-hydroxytryptamine receptor 1A

Protein Summary
Description
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli. This gene encodes a G prote ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323865
  • ENSP00000316244
  • ENSG00000178394

Symbol
  • ADRB2RL1
  • ADRBRL1
  • G-21
  • 5HT1a
  • PFMCD
  • 5-HT1A
  • 5-HT-1A
  • ADRBRL1
  • ADRB2RL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
ligand (chemical)
1
disease
0.95
chemical
0.92
protein complex
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6416.5   (req: < 5)
Gene RIFs: 264   (req: <= 3)
Antibodies: 296   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6416.5   (req: >= 5)
Gene RIFs: 264   (req: > 3)
Antibodies: 296   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2215
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 42
Pathways (35)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (23)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (344)
1 – 10 of 344
GABBR1
Tclin
Family: GPCR
Novelty: 0.00086493
Score: 0.964
Data Source: STRINGDB
POMC
Tbio
Novelty: 0.00002436
Score: 0.964
Data Source: STRINGDB
SLC6A4
Tclin
Family: Transporter
Novelty: 0.00017603
Score: 0.962
Data Source: STRINGDB
GRM2
Tchem
Family: GPCR
Novelty: 0.00132156
Score: 0.96
Data Source: STRINGDB
GABBR2
Tclin
Family: GPCR
Novelty: 0.00739771
Score: 0.959
Data Source: STRINGDB
NPY
Tbio
Novelty: 0.00012637
Score: 0.957
Data Source: STRINGDB
GNAI3
Tbio
Novelty: 0.03484857
Score: 0.952
Data Source: STRINGDB
PDYN
Tbio
Novelty: 0.00039564
Score: 0.952
Data Source: STRINGDB
ADCY1
Tchem
Family: Enzyme
Novelty: 0.01089602
Score: 0.95
Data Source: STRINGDB
GPR55
Tclin
Family: GPCR
Novelty: 0.00428199
Score: 0.947
Data Source: STRINGDB
Publication Statistics
PubMed Score  6416.50

PubMed score by year
PubTator Score  2138.32

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer