You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CLEC4M
C-type lectin domain family 4 member M

Protein Summary
Description
Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. (Microbial infection) Acts as an attachment receptor for Ebolavirus. (Microbial infection) Acts as an attachment receptor for Hepatitis C virus. (Microbial infection) Acts as an attachment receptor for HIV-1. (Microbial infection) Acts as an attachment receptor for Human coronavirus 229E. (Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5. (Microbial infection) Acts as an attachment receptor for Influenzavirus. (Microbial infection) Acts as an attachment receptor for SARS coronavirus. (Microbial infection) Acts as an attachment receptor for West-nile virus. (Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus. (Microbial infection) Acts as an attachment rece ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248228
  • ENSP00000248228
  • ENSG00000104938
  • ENST00000327325
  • ENSP00000316228
  • ENST00000359059
  • ENSP00000351954
  • ENST00000595496
  • ENSP00000470132
  • ENST00000596363
  • ENSP00000471125
  • ENST00000597522
  • ENSP00000471132

Symbol
  • CD209L
  • CD209L1
  • CD299
  • CD299
  • LSIGN
  • CD209L
  • L-SIGN
  • DCSIGNR
  • HP10347
  • DC-SIGN2
  • DC-SIGNR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
cell type or tissue
0.7
biological term
0.69
microRNA
0.63
gene perturbation
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.93   (req: < 5)
Gene RIFs: 71   (req: <= 3)
Antibodies: 397   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.93   (req: >= 5)
Gene RIFs: 71   (req: > 3)
Antibodies: 397   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
von Willebrand factor measurement
1
1
2
67.7
neutrophil count
2
2
2
44.1
leukocyte count
2
2
2
34.1
neutrophil percentage of leukocytes
1
1
1
24.1
myeloid white cell count
1
1
1
3.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
von Willebrand factor measurement
2
67.7
neutrophil count
2
44.1
leukocyte count
2
34.1
neutrophil percentage of leukocytes
1
24.1
myeloid white cell count
1
3.4
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-type lectin domain family 4 member M
VGNC:6620
455661
Mouse
MGI:1916415
69165
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-type lectin domain family 4 member M
Mouse
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H2X3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (49)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Phagosome
KEGG
C-type lectin receptor signaling pathway
KEGG
Tuberculosis
KEGG
Measles
Name
Explore in Pharos
Explore in Source
Phagosome
C-type lectin receptor signaling pathway
Tuberculosis
Measles
Gene Ontology Terms (26)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CACAO
Inferred from Physical Interaction (IPI)
AgBase
Traceable Author Statement (TAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (36)
1 – 10 of 36
CD209
Tbio
Novelty: 0.001172
p_int: 1
Score: 0.904
Data Source: BioPlex,STRINGDB
GRN
Tbio
Novelty: 0.00096395
p_int: 0.964895699
p_ni: 0.0351043
Score: 0.214
Data Source: BioPlex,STRINGDB
GFAP
Tbio
Novelty: 0.00020932
p_int: 0.924949916
p_ni: 0.075049073
p_wrong: 0.000001011
Score: 0.187
Data Source: BioPlex,STRINGDB
ICAM3
Tbio
Novelty: 0.00213474
Score: 0.833
Data Source: STRINGDB
LSP1
Tbio
Novelty: 0.00889927
Score: 0.819
Data Source: STRINGDB
KSR1
Tbio
Family: Kinase
Novelty: 0.00691155
Score: 0.809
Data Source: STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.802
Data Source: STRINGDB
ARHGEF12
Tbio
Novelty: 0.01365866
Score: 0.801
Data Source: STRINGDB
PLK3
Tchem
Family: Kinase
Novelty: 0.00646108
Score: 0.8
Data Source: STRINGDB
ACE2
Tchem
Family: Enzyme
Novelty: 0.00028408
Score: 0.643
Data Source: STRINGDB
Publication Statistics
PubMed Score  148.93

PubMed score by year
PubTator Score  99.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: