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Tbio
STAT2
Signal transducer and activator of transcription 2

Protein Classes
Protein Summary
Description
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:9020188, PubMed:23391734). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:26122121). The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314128
  • ENSP00000315768
  • ENSG00000170581
  • ENST00000557235
  • ENSP00000450751

Symbol
  • P113
  • IMD44
  • ISGF-3
  • STAT113
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
virus perturbation
1
histone modification site profile
0.83
interacting protein
0.75
transcription factor binding site profile
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 274.95   (req: < 5)
Gene RIFs: 92   (req: <= 3)
Antibodies: 931   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 274.95   (req: >= 5)
Gene RIFs: 92   (req: > 3)
Antibodies: 931   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (82)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon alpha/beta signaling
Reactome
Interleukin-20 family signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon alpha/beta signaling
Interleukin-20 family signaling
Protein-Protein Interactions (273)
1 – 10 of 273
IRF9
Tbio
Family: TF
Novelty: 0.01154411
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
STAT1
Tchem
Family: TF
Novelty: 0.00041067
p_int: 1
Score: 0.971
Data Source: BioPlex,Reactome,STRINGDB
ZNF692
Tbio
Family: TF
Novelty: 0.06511123
p_int: 0.999999294
p_ni: 6.17e-7
p_wrong: 8.9e-8
Data Source: BioPlex
TACC1
Tbio
Novelty: 0.04784031
p_int: 0.999917728
p_ni: 0.000082252
p_wrong: 2e-8
Score: 0.158
Data Source: BioPlex,STRINGDB
MYCBP2
Tbio
Family: Enzyme
Novelty: 0.00336142
p_int: 0.999840277
p_ni: 0.000159723
Score: 0.164
Data Source: BioPlex,STRINGDB
DPP9
Tchem
Family: Enzyme
Novelty: 0.01345112
p_int: 0.999811913
p_ni: 0.000188072
p_wrong: 1.5e-8
Data Source: BioPlex
INSYN2
Tdark
p_int: 0.999780745
p_ni: 0.000219255
Data Source: BioPlex
LIPT1
Tdark
Family: Enzyme
Novelty: 0.0746733
p_int: 0.998346019
p_ni: 0.00165391
p_wrong: 7.1e-8
Score: 0.455
Data Source: BioPlex,STRINGDB
FBXO45
Tbio
Novelty: 0.08978487
p_int: 0.996673164
p_ni: 0.000060706
p_wrong: 0.00326613
Score: 0.159
Data Source: BioPlex,STRINGDB
TRRAP
Tbio
Novelty: 0.0211297
p_int: 0.991443218
p_ni: 0.008556782
Score: 0.182
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  274.95

PubMed score by year
PubTator Score  265.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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