Protein Classes
Protein Summary
Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells. (Microbial infection) Acts as an attachment receptor for HIV-1 and HIV-2. (Microbial infection) Acts as an attachment receptor for Ebolavirus. (Microbial infection) Acts as an atta ...more
- ENST00000204801
- ENSP00000204801
- ENSG00000090659
- ENST00000315591
- ENSP00000315407
- ENST00000315599
- ENSP00000315477
- ENST00000354397
- ENSP00000346373
- ENST00000394161
- ENSP00000377716
- ENST00000601256
- ENSP00000470658
- ENST00000601951
- ENSP00000468827
- ENST00000602261
- ENSP00000471137
- CLEC4L
- CDSIGN
- CLEC4L
- DC-SIGN
- DC-SIGN1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological term | 0.99 | ||
cellular component | 0.82 | ||
cell type or tissue | 0.77 | ||
phenotype | 0.67 | ||
gene perturbation | 0.6 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 749.2 (req: < 5)
Gene RIFs: 270 (req: <= 3)
Antibodies: 1369 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 749.2 (req: >= 5)
Gene RIFs: 270 (req: > 3)
Antibodies: 1369 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
---|
PDB Structure Id | M.W. | Resolution | Pub Year |
---|
Pathways (11)
Reactome (6)
KEGG (4)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 6
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Butyrophilin (BTN) family interactions | ||||
Reactome | C-type lectin receptors (CLRs) | ||||
Reactome | CD209 (DC-SIGN) signaling | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
Butyrophilin (BTN) family interactions | ||||
C-type lectin receptors (CLRs) | ||||
CD209 (DC-SIGN) signaling | ||||
Immune System | ||||
Gene Ontology Terms (31)
Functions (6)
Components (8)
Processes (17)
Items per page:
10
1 – 6 of 6
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (127)
1 – 10 of 127
CLEC4M
Novelty: 0.01055864
p_int: 1
Score: 0.904
Data Source: BioPlex,STRINGDB
FAM217B
Novelty: 3
p_int: 0.999998966
p_ni: 0.000001012
p_wrong: 2.3e-8
Score: 0.221
Data Source: BioPlex,STRINGDB
HTR1B
Family: GPCR
Novelty: 0.00089155
p_int: 0.999614359
p_wrong: 0.00038564
Score: 0.689
Data Source: BioPlex,STRINGDB
HMGCR
Family: Enzyme
Novelty: 0.00056109
p_int: 0.91367529
p_ni: 0.08632471
Score: 0.345
Data Source: BioPlex,STRINGDB
ZNF703
Novelty: 0.05197807
p_int: 0.811260758
p_ni: 0.18873923
p_wrong: 1.2e-8
Score: 0.187
Data Source: BioPlex,STRINGDB
ICAM3
Novelty: 0.00219774
Score: 0.997
Data Source: Reactome,STRINGDB
ICAM2
Novelty: 0.00637658
Score: 0.982
Data Source: Reactome,STRINGDB
BTN2A1
Novelty: 0.03671686
Score: 0.932
Data Source: Reactome,STRINGDB
LSP1
Novelty: 0.01170291
Score: 0.92
Data Source: STRINGDB
RAF1
Family: Kinase
Novelty: 0.00165174
Score: 0.908
Data Source: STRINGDB
Publication Statistics
PubMed Score 749.20
PubMed score by year
PubTator Score 301.43
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MSDSKEPRLQQLGLLEEEQLRGLGFRQTRGYKSLAGCLGHGPLVLQLLSFTLLAGLLVQVSKVPSSISQE
1-70
QSRQDAIYQNLTQLKAAVGELSEKSKLQEIYQELTQLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEK
70-140
SKLQEIYQELTWLKAAVGELPEKSKMQEIYQELTRLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKS
140-210
KQQEIYQELTRLKAAVGELPEKSKQQEIYQELTQLKAAVERLCHPCPWEWTFFQGNCYFMSNSQRNWHDS
210-280
ITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNN
280-350
VGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASCSRDEEQFLSPAPATPNPPPA
350-404
MSDSKEPRLQQLGLLEEEQLRGLGFRQTRGYKSLAGCLGHGPLVLQLLSFTLLAGLLVQVSKVPSSISQEQSRQDAIYQNLTQLKAAVGELSEKSKLQEIYQELTQLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQEIYQELTWLKAAVGELPEKSKMQEIYQELTRLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQELTQLKAAVERLCHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASCSRDEEQFLSPAPATPNPPPA
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