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Tdark
ARL6IP6
ADP-ribosylation factor-like protein 6-interacting protein 6

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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.62   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.62   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
1
1
25.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
25.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor like GTPase 6 interacting protein 6
VGNC:79
736630
Mouse
MGI:1929507
65103
Rat
RGD:1564819
499798
Dog
ADP ribosylation factor like GTPase 6 interacting protein 6
VGNC:38121
609760
Horse
ADP ribosylation factor like GTPase 6 interacting protein 6
VGNC:15524
100050511
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor like GTPase 6 interacting protein 6
Mouse
Rat
Dog
ADP ribosylation factor like GTPase 6 interacting protein 6
Horse
ADP ribosylation factor like GTPase 6 interacting protein 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8N6S5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (27)
1 – 10 of 27
PNPO
Tchem
Family: Enzyme
Novelty: 0.00919993
p_int: 0.988615387
p_ni: 0.007537365
p_wrong: 0.003847247
Score: 0.2
Data Source: BioPlex,STRINGDB
DUSP3
Tchem
Family: Enzyme
Novelty: 0.00518547
p_int: 0.984791669
p_ni: 0.014546794
p_wrong: 0.000661537
Score: 0.527
Data Source: BioPlex,STRINGDB
PMVK
Tchem
Family: Enzyme
Novelty: 0.00468598
p_int: 0.982253413
p_ni: 0.017691754
p_wrong: 0.000054832
Score: 0.186
Data Source: BioPlex,STRINGDB
SNX3
Tbio
Novelty: 0.02703152
p_int: 0.968106343
p_ni: 0.02029123
p_wrong: 0.011602427
Data Source: BioPlex
GSTM1
Tbio
Family: Enzyme
Novelty: 0.00023264
p_int: 0.951871269
p_ni: 0.048114168
p_wrong: 0.000014563
Score: 0.21
Data Source: BioPlex,STRINGDB
NAA50
Tbio
Family: Enzyme
Novelty: 0.01843508
p_int: 0.934615152
p_ni: 0.065384848
Score: 0.223
Data Source: BioPlex,STRINGDB
NME2P1
Tdark
Family: Kinase
p_int: 0.932163101
p_ni: 0.067836899
Data Source: BioPlex
CHMP4A
Tbio
Novelty: 0.01163844
p_int: 0.928729602
p_ni: 0.071255639
p_wrong: 0.000014759
Score: 0.237
Data Source: BioPlex,STRINGDB
CBFB
Tchem
Family: TF
Novelty: 0.04825679
p_int: 0.911853475
p_ni: 0.015150555
p_wrong: 0.07299597
Score: 0.2
Data Source: BioPlex,STRINGDB
YKT6
Tbio
Novelty: 0.01591063
p_int: 0.908840792
p_ni: 0.089154338
p_wrong: 0.002004871
Score: 0.179
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  2.62

PubMed score by year
PubTator Score  4.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer